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TSPAN32

From Wikipedia, the free encyclopedia
TSPAN32
Identifiers
AliasesTSPAN32, ART1, PHEMX, PHMX, TSSC6, tetraspanin 32
External IDsOMIM: 603853; MGI: 1350360; HomoloGene: 10650; GeneCards: TSPAN32; OMA:TSPAN32 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005705
NM_139022
NM_139024

NM_001128080
NM_001128081
NM_001128082
NM_020286

RefSeq (protein)

NP_620591

NP_001121552
NP_001121553
NP_001121554
NP_064682

Location (UCSC)Chr 11: 2.3 – 2.32 MbChr 7: 142.56 – 142.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tetraspanin-32 is a protein that in humans is encoded by the TSPAN32 gene.[5][6][7]

Function

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This gene is described as a member of the tetraspanin superfamily whose expression is confined to hematopoietic tissues.[7]

Clinical significance

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This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is located among several imprinted genes; however, this gene, as well as the tumor-suppressing subchromosomal transferable fragment 4 (TSSC4), escapes imprinting. This gene may play a role in malignancies and disease that involve this region as well as hematopoietic cell function.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000064201Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000244Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lee MP, Brandenburg S, Landes GM, Adams M, Miller G, Feinberg AP (Apr 1999). "Two novel genes in the center of the 11p15 imprinted domain escape genomic imprinting". Hum Mol Genet. 8 (4): 683–90. doi:10.1093/hmg/8.4.683. PMID 10072438.
  6. ^ Nicholson RH, Pantano S, Eliason JF, Galy A, Weiler S, Kaplan J, Hughes MR, Ko MS (Sep 2000). "Phemx, a novel mouse gene expressed in hematopoietic cells maps to the imprinted cluster on distal chromosome 7". Genomics. 68 (1): 13–21. doi:10.1006/geno.2000.6277. PMID 10950922.
  7. ^ a b c "Entrez Gene: TSPAN32 tetraspanin 32".

Further reading

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