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Uroplakin-1a

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(Redirected from TSPAN21)
UPK1A
Identifiers
AliasesUPK1A, TSPAN21, UP1A, UPIA, UPKA, uroplakin 1A
External IDsOMIM: 611557; MGI: 98911; HomoloGene: 21383; GeneCards: UPK1A; OMA:UPK1A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007000
NM_001281443

NM_026815

RefSeq (protein)

NP_001268372
NP_008931

NP_081091

Location (UCSC)Chr 19: 35.67 – 35.68 MbChr 7: 30.3 – 30.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Uroplakin-1a (UP1a) is a protein that in humans is encoded by the UPK1A gene.[5][6][7]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains.

The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins.

UP1a may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105668Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006313Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lobban ED, Smith BA, Hall GD, Harnden P, Roberts P, Selby PJ, Trejdosiewicz LK, Southgate J (Dec 1998). "Uroplakin gene expression by normal and neoplastic human urothelium". Am J Pathol. 153 (6): 1957–67. doi:10.1016/S0002-9440(10)65709-4. PMC 1866332. PMID 9846985.
  6. ^ Yuasa T, Yoshiki T, Isono T, Tanaka T, Hayashida H, Okada Y (Sep 1999). "Expression of transitional cell-specific genes, uroplakin Ia and II, in bladder cancer: detection of circulating cancer cells in the peripheral blood of metastatic patients". Int J Urol. 6 (6): 286–92. doi:10.1046/j.1442-2042.1999.00064.x. PMID 10404304. S2CID 43597402.
  7. ^ a b "Entrez Gene: UPK1A uroplakin 1A".

Further reading

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