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Retinoid X receptor gamma

From Wikipedia, the free encyclopedia
RXRG
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRXRG, NR2B3, RXRC, Retinoid X receptor gamma, RXR-gamma, RXRgamma
External IDsOMIM: 180247; MGI: 98216; HomoloGene: 21373; GeneCards: RXRG; OMA:RXRG - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001256570
NM_001256571
NM_006917

NM_001159731
NM_009107

RefSeq (protein)

NP_001243499
NP_001243500
NP_008848

NP_001153203
NP_033133

Location (UCSC)Chr 1: 165.4 – 165.45 MbChr 1: 167.43 – 167.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Retinoid X receptor gamma (RXR-gamma), also known as NR2B3 (nuclear receptor subfamily 2, group B, member 3) is a nuclear receptor that in humans is encoded by the RXRG gene.[5][6]

Function

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This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms heterodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[6]

See also

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Interactions

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Retinoid X receptor gamma has been shown to interact with ITGB3BP.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143171Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015843Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Almasan A, Mangelsdorf DJ, Ong ES, Wahl GM, Evans RM (April 1994). "Chromosomal localization of the human retinoid X receptors". Genomics. 20 (3): 397–403. doi:10.1006/geno.1994.1193. PMID 8034312.
  6. ^ a b "Entrez Gene: RXRG retinoid X receptor, gamma".
  7. ^ Li D, Wang F, Samuels HH (Dec 2001). "Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation". Mol. Cell. Biol. 21 (24): 8371–84. doi:10.1128/MCB.21.24.8371-8384.2001. PMC 100002. PMID 11713274.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.