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FOXO6

From Wikipedia, the free encyclopedia
FOXO6
Identifiers
AliasesFOXO6, forkhead box O6
External IDsOMIM: 611457; MGI: 2676586; HomoloGene: 82395; GeneCards: FOXO6; OMA:FOXO6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001291281

NM_194060

RefSeq (protein)

NP_001278210

NP_918949

Location (UCSC)Chr 1: 41.36 – 41.38 MbChr 4: 120.12 – 120.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Forkhead box O6 is a protein that in humans is encoded by the FOXO6 gene.[5]

FoxO6 is expressed in the liver, skeletal muscle, and the hippocampus of the brain.[6] In the liver, FoxO6 normally promotes gluconeogenesis in the fasted state, but insulin blocks Fox06 upon feeding.[6] In a condition of insulin resistance insulin fails to block FoxO6 resulting in continued gluconeogenesis even upon feeding.[6]

References

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  1. ^ a b c ENSG00000281518 GRCh38: Ensembl release 89: ENSG00000204060, ENSG00000281518Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052135Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Forkhead box O6".
  6. ^ a b c Lee S, Dong HH (2017). "FoxO integration of insulin signaling with glucose and lipid metabolism". Journal of Endocrinology. 233 (2): R67–R79. doi:10.1530/JOE-17-0002. PMC 5480241. PMID 28213398.

Further reading

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