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Glycoprotein IX

From Wikipedia, the free encyclopedia

GP9
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGP9, CD42a, GPIX, Glycoprotein IX, glycoprotein IX platelet
External IDsOMIM: 173515; MGI: 1860137; HomoloGene: 144; GeneCards: GP9; OMA:GP9 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000174

NM_018762

RefSeq (protein)

NP_000165

NP_061232

Location (UCSC)Chr 3: 129.06 – 129.06 MbChr 6: 87.76 – 87.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glycoprotein IX (platelet) (GP9) also known as CD42a (Cluster of Differentiation 42a), is a human gene.[5]

Platelet glycoprotein IX (GP9) is a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib (GP Ib), a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor (VWF; MIM 193400) (known as the Glycoprotein Ib-IX-V Receptor Complex). The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with GP9 and platelet glycoprotein V (GP5; MIM 173511).[supplied by OMIM][5]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169704Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030054Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: GP9 glycoprotein IX (platelet)".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.