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CD8A

From Wikipedia, the free encyclopedia

CD8A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCD8A, CD8, Leu2, MAL, p32, CD8a molecule
External IDsOMIM: 186910; MGI: 88346; HomoloGene: 133777; GeneCards: CD8A; OMA:CD8A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001145873
NM_001768
NM_171827

NM_001081110
NM_009857

RefSeq (protein)

NP_001139345
NP_001759
NP_741969
NP_001369627

NP_001074579
NP_033987

Location (UCSC)Chr 2: 86.78 – 86.81 MbChr 6: 71.35 – 71.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

T-cell surface glycoprotein CD8 alpha chain (Cluster of Differentiation 8a), is a protein encoded by CD8A gene.[5]

Function

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The CD8 protein is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen-presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to variable domain of immunoglobulin light chains. This gene encodes the CD8 alpha chain isoforms. Two alternative transcripts encoding distinct isoforms, one membrane associated and one secreted, have been identified.[5]

Interactions

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CD8A has been shown to interact with:

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000153563Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053977Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: CD8A CD8a molecule".
  6. ^ Doucey MA, Goffin L, Naeher D, Michielin O, Baumgärtner P, Guillaume P, Palmer E, Luescher IF (January 2003). "CD3 delta establishes a functional link between the T cell receptor and CD8". J. Biol. Chem. 278 (5): 3257–64. doi:10.1074/jbc.M208119200. PMID 12215456.
  7. ^ a b Gao GF, Willcox BE, Wyer JR, Boulter JM, O'Callaghan CA, Maenaka K, Stuart DI, Jones EY, Van Der Merwe PA, Bell JI, Jakobsen BK (May 2000). "Classical and nonclassical class I major histocompatibility complex molecules exhibit subtle conformational differences that affect binding to CD8alphaalpha". J. Biol. Chem. 275 (20): 15232–8. doi:10.1074/jbc.275.20.15232. PMID 10809759.
  8. ^ Gao GF, Tormo J, Gerth UC, Wyer JR, McMichael AJ, Stuart DI, Bell JI, Jones EY, Jakobsen BK (June 1997). "Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2". Nature. 387 (6633): 630–4. Bibcode:1997Natur.387..630G. doi:10.1038/42523. PMID 9177355. S2CID 4267617.
  9. ^ Sanders SK, Giblin PA, Kavathas P (September 1991). "Cell-cell adhesion mediated by CD8 and human histocompatibility leukocyte antigen G, a nonclassical major histocompatibility complex class 1 molecule on cytotrophoblasts". J. Exp. Med. 174 (3): 737–40. doi:10.1084/jem.174.3.737. PMC 2118947. PMID 1908512.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.