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Authors: Xu, Feng | Huang, Jia

Article Type: Research Article

Abstract: BACKGROUND: Grape seed proanthocyanidin extract (GSPE) has a certain resistance to contrast light, which makes the boundary of the imaging image unclear. OBJECTIVE: Because of this, an image processing algorithm is needed to process the contrast image to study the role of GSPE in the process of anti-ultraviolet. METHODS: In this paper, the fuzzy edges of contrast images were processed by deep learning algorithm, and the changes of VEGF and PEDF expression in HaCaT cells before and after UVA irradiation and after GSPE intervention were studied. RESULTS: The experiment results show that after processing, the edge and boundary of the …image become clear and separable, which can be used to compare and analyze the test process. The image comparison results show that GSPE can down regulate the expression of VEGF gene and protein, and up regulate the expression of PEDF gene and protein. The synergistic effect of GSPE and GSPE can inhibit angiogenesis. It is confirmed that GSPE has the effect of anti-ultraviolet ray induced early angiogenesis. Show more

Keywords: HaCaT cells, SURF, deep learning, binary image

DOI: 10.3233/THC-202655

Citation: Technology and Health Care, vol. 29, no. 2, pp. 381-391, 2021

Authors: Chai, Linsong | Huang, Yunshi | Guo, Xinqi | Xiong, Ailing | Lin, Bingbing | Huang, Jia

Article Type: Review Article

Abstract: BACKGROUND: Non-invasive brain stimulation has been widely used as an adjunctive treatment for aphasia following stroke. OBJECTIVE: The aim of this study was to investigate the effect of non-invasive brain stimulation as an adjunctive treatment on naming function in aphasia following stroke. METHODS: This review included randomized controlled trials (RCTs) involving 5 databases (Web of Science, Embase, Cochrane Library, OVID and PubMed) that investigated the effects of electrical stimulation on stroke patients. The search included literature published up to November 2023. RESULTS: We identified 18 studies, and the standardized mean differences (SMDs) showed that the effect sizes of TMS and …tDCS were small to medium. Moreover, the treatment effects persisted over time, indicating long-term efficacy. CONCLUSION: This study suggested that NIBS combined with speech and language therapy can effectively promote the recovery of naming function in patients with post-stroke aphasia (PSA) and that the effects are long lasting. Show more

Keywords: Meta-analysis, post-stroke aphasia, noninvasive brain stimulation, speech-language therapy, naming

DOI: 10.3233/NRE-240065

Citation: NeuroRehabilitation, vol. 54, no. 4, pp. 543-561, 2024

Authors: Tholomier, Côme | Marcq, Gautier | Shinde-Jadhav, Surashri | Ayoub, Mina | Huang, Jia Min | Kool, Ronald | Skowronski, Rodrigo | Brimo, Fadi | Mansure, Jose Joao | Kassouf, Wassim

Article Type: Research Article

Abstract: BACKGROUND: New bladder preserving strategies are needed for muscle invasive bladder cancer (MIBC). Combined therapy of immune-checkpoint inhibitors and radiation was shown to have synergistic antitumoral effects in preclinical studies. OBJECTIVES: We aim to evaluate whether the sequence of administration of this combined therapy impacts antitumoral response. METHODS: We developed an in-vivo syngeneic MIBC mouse model where murine bladder cancer cells (MB49) were injected subcutaneously in the right flank of C57BL/6 mice. Mice were then randomized to the following treatments: control, anti-programmed cell death ligand 1 (PD-L1) alone, radiation alone (XRT) consisting of 6.25 Gy x2 fractions, concurrent anti-PD-L1 with …XRT, neoadjuvant anti-PD-L1 followed by XRT, or XRT followed by adjuvant anti-PD-L1 therapy. Tumor growth, survival, and rate of response were analyzed. RESULTS: Total of 60 mice were randomized. One-way analysis of variance showed statistically significant difference in tumor growth rate across the treatment arms (p  = 0.029). Importantly, timing of immunotherapy (neoadjuvant, concurrent, or adjuvant) did not alter either tumor growth or survival (p  > 0.05). The rate of response was also similar in each combination arm (p  > 0.05). CONCLUSION: Combining anti-PD-L1 immunotherapy and radiation therapy offers optimal antitumoral responses. Timing of immunotherapy (neoadjuvant, concurrent, or adjuvant) does not appear to affect outcomes. Whether the toxicity profile differs across various sequential deliveries of combination therapy requires further evaluation. Show more

Keywords: Urinary bladder neoplasms, carcinoma, transitional cell, immunotherapy, programmed cell death 1 ligand 2 protein; radiotherapy, combined modality therapy

DOI: 10.3233/BLC-200315

Citation: Bladder Cancer, vol. 6, no. 3, pp. 295-302, 2020

Authors: Tang, Hui-Wen | Wang, Zha-Gen | Huang, Jia-Hu | Zhang, Guo-Qin | Xu, Yun-Feng | Zheng, Lu-Lu | Li, Ting-Jun

Article Type: Research Article

Abstract: BACKGROUND: Acute appendicitis in children refers to the acute inflammation of the appendix, which accounts for 20% ∼ 30% of cases of acute abdomen in pediatric surgery. OBJECTIVE: This study aimed to establish a decision tree model of complicated appendicitis in children using appendiceal ultrasound combined with an inflammatory index and evaluated its clinical efficacy in pediatric patients. METHODS: A total of 395 children admitted to the Emergency Department of the Shanghai Children’s Hospital from January 2018 to December 2021 and diagnosed with appendicitis by postoperative pathology were retrospectively analyzed. According to the postoperative pathology, the children were divided into …a complicated and non-complicated appendicitis group, respectively. Routine laboratory inflammatory indicators, including white blood cell count, N(%), neutrophil (Neu) count, Neu/lymphocyte ratio (NLR), C-reactive protein (CRP), and procalcitonin were collected from the two groups. Collecting data on ultrasound examination of the appendix includes whether the appendix diameter is thickened, whether the echogenicity of the mesenteric rim surrounding the appendix is enhanced, whether there is rich blood supply in the appendix, and whether there are fecaliths in the appendix lumen. The risk factors for complicated appendicitis were screened out by univariate and multivariate logistic regression analyses, the binary logistic regression prediction and decision tree models were established, respectively, and the receiver operating characteristic (ROC) curve was used to verify the accuracy of the two prediction models. RESULTS: Binary logistic regression analysis showed that CRP, NLR, the presence of an appendicolith, and peripheral retina echo enhancement were independent risk factors for complicated appendicitis in children (P < 0.05). The decision tree model had an overall accuracy of 79%, an area under the ROC curve (AUC) of 0.809 (95% confidence interval [CI] 0.780–0.865), and sensitivity and specificity of 71.3% and 77.7%, respectively. The logistic regression model had an overall accuracy of 74.9%, an AUC value of 0.823 (95% CI, 0.765–0.853), a sensitivity value of 80.3%, and a specificity of 71.8%. CONCLUSION: This predictive model, based on ultrasound of the appendix combined with inflammatory markers, provides a useful method to assist pediatric emergency physicians in diagnosing childhood appendicitis. The decision tree model reflected the interaction of various indexes, and the model was simple, intuitive, and effective. Show more

Keywords: Complicated appendicitis, appendiceal ultrasound, inflammatory index, decision tree model, children

DOI: 10.3233/THC-230285

Citation: Technology and Health Care, vol. 31, no. 6, pp. 2319-2329, 2023

Authors: Tao, Jing | Liu, Jiao | Liu, Weilin | Huang, Jia | Xue, Xiehua | Chen, Xiangli | Wu, Jinsong | Zheng, Guohua | Chen, Bai | Li, Ming | Sun, Sharon | Jorgenson, Kristen | Lang, Courtney | Hu, Kun | Chen, Shanjia | Chen, Lidian | Kong, Jian

Article Type: Research Article

Abstract: The aim of this study is to investigate and compare how 12-weeks of Tai Chi Chuan and Baduanjin exercise can modulate brain structure and memory function in older adults. Magnetic resonance imaging and memory function measurements (Wechsler Memory Scale-Chinese revised, WMS-CR) were applied at both the beginning and end of the study. Results showed that both Tai Chi Chuan and Baduanjin could significantly increase grey matter volume (GMV) in the insula, medial temporal lobe, and putamen after 12-weeks of exercise. No significant differences were observed in GMV between the Tai Chi Chuan and Baduanjin groups. We also found that compared …to healthy controls, Tai Chi Chuan and Baduanjin significantly improved visual reproduction subscores on the WMS-CR. Baduanjin also improved mental control, recognition, touch, and comprehension memory subscores of the WMS-CR compared to the control group. Memory quotient and visual reproduction subscores were both associated with GMV increases in the putamen and hippocampus. Our results demonstrate the potential of Tai Chi Chuan and Baduanjin exercise for the prevention of memory deficits in older adults. Show more

Keywords: Aging, Baduanjin, memory, mind-body exercise, Tai Chi Chuan, voxel-based morphometry

DOI: 10.3233/JAD-170477

Citation: Journal of Alzheimer's Disease, vol. 60, no. 2, pp. 389-400, 2017