(311) HYALURONIC ACID INJECTION IN LIFELONG PREMATURE EJACULATION

The therapeutic management ofPremature long-life ejaculation (PE) ranges from behavioral therapy to pharmacological treatments. Hyaluronic acid (HA) injection into the glans penis is a non-surgical procedure, intended to reduce glans hypersensitivity, improving the Intravaginal Ejaculation Latency Time (IELT). In this pilot study, we tested the effectiveness of a new technique based on a single HA injection into the frenulum of the glans, to improve IELT in a sample of patients affected by PE.

IELT was evaluated for each couple. We evaluated also International Index Ercectile Function (IIEF) and Premature Ejaculation Diagnostic Tool (PELT). All patients signed the informed consent. 8 mg of hyaluronic acid sodium salt (IBSA), without local anesthesia, were injected with a 27 G needle at the level of the frenulum of prepuce, corresponding to a triangle that we have named MONAVER (abbreviation form inventors, Mondaini-Aversa). After Injection a light compressive dressing was applied to the penis for 24h. All patients completed the VAS SCALE for pain.

We observed a significant increase of the IELT, in 31 males (25-50 years) enroled in the study, after 1 (median 73.3, IQR 66.2-79.9 seconds) and 2 months (66.2, 63.1-73.9) that gradually decreased at 3-months, remaining still significantly higher than at baseline (34.8, 30.9-37.4). PELT and IIEF questionnaires significantly improved compared to baseline in the first two months of follow-up (p < 0.001).

The preliminary results emerging from this pilot study, highlight the effectiveness of this new HA injection approach, although a larger sample and longer follow-up time are needed to standardize the procedure.

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