The small city of Sitges parties big. The nightlife is thumping, the people are gorgeous and the annual Carnival festival is utterly epic. A countercultural touchstone, Sitges is lively and very LGBT friendly. Native food and beverage is sublime—you simply must sample the Malvasia wine, made from grapes descending from Ancient Greece. Don’t miss the Museu Romàntic "Can Llopis" or, if you’re in Sitges in October, the world-renowned Sitges Film Festival, a cinematic extravaganza of horror, sci-fi and fantasy.

A popular holiday destination on the Costa Brava, the former fishing village of Lloret de Mar offers an appealing climate and great scenery. Visit the narrow streets of the Old Town and sights such as Santa Clotilde Gardens and the Maritime Museum. Take to the waves at Water World or for a variety of water sports in the Mediterranean. A handful of excellent beaches round out the offerings of this Catalonian family resort, easily reached by car from Barcelona.

Tossa del Mar has beautiful beaches—and tourists flock to them in summer, so make sure you have a reservation if you’re planning to visit in high season. Enjoy the seafront restaurants (and, of course, fresh-caught fish specialties) and many tapas bars in this charming Catalan town.

Salou, on the Costa Dorada, nestles between quaint Cambrils and calm La Pineda. Just seven miles south of elegant Tarragona, the compact resort town is a family favorite, due in no small part to the existence of Port Aventura and Aquopolis theme parks. Gentle beaches and a slew of exciting fiestas in August add to Salou's appeal for families.

Most visitors to Fiumicino arrive by plane and immediately continue on to Rome, but—in addition to being home to Italy’s busiest airport—the coastal town doubles as a beach resort during the summer months. There’s also Ostia Antica archaeological site, which is just a short drive away.

From Shoreditch’s swaggering style to Camden’s punky vibe and chic Portobello Road, London is many worlds in one. The city’s energy means that no two days are the same. Explore royal or historic sites, tick off landmarks from your bucket list, eat and drink in exclusive Michelin-starred restaurants, enjoy a pint in a traditional pub, or get lost down winding cobbled streets and see what you stumble across – when it comes to London, the possibilities are endless.

Once known for smog, traffic and tacky architecture, Athens is a city reformed thanks to fortunes brought by the 2004 Summer Olympics. Spotless parks and streets, an ultra-modern subway, new freeways, an accessible airport and all signs in perfect English make the city easily negotiable. Meriting more than a stopover en route to the islands, sophisticated Athens sites include many pillars of Western history, from the Acropolis to the Temple of Olympian Zeus, as well as treasures in the National Archaeological Museum.

Walk the Freedom Trail the first time you visit Boston and you'll quickly get a sense of this coastal city's revolutionary spirit and history. But make sure you also explore some of Boston's fine museums (try the Isabella Stewart Gardner, featuring masterpieces displayed in their collector's mansion) and old neighborhoods (like the North End, Boston's Little Italy). You can't claim to have experienced real Boston culture, though, until you've watched a Red Sox game from the bleachers.

Dubbed the Queen City, Charlotte reigns over a 300-square-mile (482-square-kilometer) hodgepodge of neighborhoods that spin out from the banks of the Catawba River. From brewery-heavy art districts to historical corridors dripping in charm, consider Charlotte a crowd pleaser.

Atlanta has been dubbed everything from the "capital of the new South" and "the next international city" to "the best place to do business." It's also a great place to visit. Fueled by the prosperity of local mega companies like Coca Cola and Holiday Inn, the prestige of hosting the 1996 Summer Olympic Games and the energy of young upwardly mobile types who have migrated to the city in droves - Atlanta is on fire. And this time it's a good thing. From world-class restaurants and a myriad of cultural attractions to a hip nightlife and sporting events galore, the city is cosmopolitan in every sense of the word. But Atlanta has also managed to maintain its historic character. Stop by the Atlanta History Center or visit the Martin Luther King Jr. Historical Site, a moving tribute to an American icon. Browse through the former home of famous author Margaret Mitchell or pop into the Jimmy Carter Library and Museum for details on the life and times of the former president and his family. Whether you choose modern urban endeavors or old southern pleasures, Atlanta will not disappoint.

With live music to be heard all across town, 24/7, 365 days a year, Music City lives up to its name. From honky-tonk bands jamming at Tootsie’s Orchid Lounge to songwriters in the round at the Bluebird Cafe and country music legends rocking the Grand Ole Opry, you never know who you might see. The creative spirit from Nashville's music landscape flows into the area's myriad art galleries, up-and-coming fashion scene, historic landmarks and chef-driven restaurants.

From the Magic Kingdom to magical spa treatments, Orlando sparkles with the promise of adventure. Spend a day exploring the world-famous Disney theme parks or screaming your head off on a Universal Studios roller coaster. For a less adrenaline-pumping afternoon, enjoy the quiet natural beauty of the Harry P. Leu Gardens or enjoy a seaweed scrub at a luxury day spa. Savor fresh and local ingredients at one of Orlando’s James Beard-nominated restaurants.

Fort Lauderdale’s canals and charm have earned it the nickname “The Venice of America.” The beaches offer 23 miles of golden sand, lively with the spirited antics of happy vacationers. Sail the blue-green waters on a chartered catamaran, or dive beneath the surface to meet-and-greet the local sea life. Shopping and dining al fresco on Las Olas Boulevard is one of Fort Lauderdale’s greatest pleasures, thanks to adorable shops and prime people-watching.

Miami is hot hot hot! And it’s not just the sultry weather. Here, the nightlife is scorching, thanks to a strong Latin influence and spicy salsa culture. Dance the noche away in a nightclub, or indulge in a fancy meal at one of the city’s celebrity-owned restaurants. By day, hit the beach of course, or have yourself a walkabout, taking in Miami’s colorful art deco architecture. Grab a Cuban sandwich in Little Havana, then ride the vintage carousel at Virginia Key Beach Park.