Entertainment can be experienced in a variety of ways in Santiago de Cuba.  Your ears may find comfort in the Casa de Las Tradiciones, a venue of the Trivoli neighbourhood where Cuba's finest musicians gather for improvisation;  your mouth, in Paladar Salon Tropical, where mainstays of the national cuisine arrive in generous portions; your eyes, in the Jardin de Los Helechos, home to a floral explosion of 90 types of orchids and 350 types of ferns.The gentile Tivolí district, some of Santiago de Cuba's most exciting ensembles, singers and soloists take turns improvising. Friday nights are reserved for straight-up, classic trova, à la Ñico Saquito and the like.

Set in rugged, mountainous territory in the east, Cuba's fourth largest city is known as the City of Parks. Columbus called the area the most beautiful land eyes have ever seen and much of the surrounding area hasn't changed. Officially called San Isidro de Holguin, the city's elegant plazas, scatter of colonial buildings and few museums make for a pleasant daytrip. More wonders lie offshore. Swim with dolphins in Bahia de Naranjo Nature Park. Dive to sites off Playa Esmeralda and Guardalavaca.

U.S. citizens still need to jump through a few hoops to visit Cuba, but as visitors from around the world know, this island offers some amazing opportunities for cultural exchange. Havana is a mix of old-world architecture and of-the-moment culture. Head out of the capital city to the small town of Trinidad to see more Spanish colonial architecture. It’s a UNESCO World Heritage Site and a fantastic home base for a visit to the Valley of the Sugar Mills, a pocket of land that formerly served as the centre of Cuba’s sugar industry.

Cayo Coco, an island just north of mainland Cuba, has some of the world’s most gorgeous beaches—think superfine white sand and shallow, clear water. It’s popular with European travelers seeking a sunny escape at one of the island’s beach-side resorts. Snorkeling and diving are fantastic.

Cuba's top beach destination sits on a 13-mile-long peninsula with powder soft sands lapped by waters of the Kawama Channel. Resort hotels teem along the shore that U.S. celebrities and gangsters, including Capone, discovered in the 1920s. Clubs and bars provide mojitos and merriment, after long days baking on the beach, golfing, diving or deep sea fishing. Rent a scooter or hop aboard an open-air tourist train or bus to see more of this stunning spot. Caves, keys and virgin forest add to the area's allure.

A city trapped in time, Havana captures the imagination like no other. Faded glamour meets careful colonial-era reconstruction with a backdrop of irresistible colour. Walk El Malecón, the walkway bordering the ocean; visit Old Havana and the Catedral de San Cristóbal; and listen for salsa music, open-air bazaars and parties that last all night.

Isla Mujeres offers a wide variety of tempting options for beach lovers, and is a relative bargain. Snorkel with tropical fish amid coral reefs, skim the blue waters by kayak or boat, or windsurf along the shores of soft, sandy beaches. On land, you can sunbathe, dine on seafood, dance to Latin rhythms, tour on a moped or belly up to the bar for fresh, delicious drinks.

It’s not just for spring-breakers. Cancun, with its golden beaches and perfect climate, is the premiere coastal destination in Mexico. And while there is certainly a 365-day party available for college students, resorts cater well to families and to those seeking solitude. This Yucatan paradise is also the gateway to the ruins of Tulum and Chichén Itzá.

Get the experience of visiting two island colonies in the same 37 square miles. Saint Maarten/Saint Martin's spicy marriage of Caribbean, French and Dutch cultures matches its physical diversity: the island is both urban and untamed, with rain forest-like landscapes, white beaches, and amazing caves and wildlife.

With nine bays and 36 beaches, Huatulco is ideal for anyone who loves the sun. It's not an overdeveloped resort town, but the hotels are comfortable—even luxurious. Ecotourism is gaining in popularity, so take a break from sunbathing and try river rafting or a hike through the jungle.

Is there any possible way Las Vegas could not be on our "best nightlife" list? The only way we could possibly omit it is on a technicality—since you can do pretty much anything 24/7 in Vegas, it might be wrong to call it "nightlife."