Opinion

Video

Frontline BTKi Selection

Key opinion leaders examine the use of continuous Bruton's tyrosine kinase inhibitor therapy in front-line treatment, strategies for sequencing therapies, and the potential incorporation of obinutuzumab into treatment regimens.

  1. Dr Lamanna: When considering continuous BTKi therapy in the front-line setting, how do you select among available treatment options?
    1. How do you select patients for acala vs zanu?
    2. In which patients would you consider the addition of obinutuzumab?
  2. Dr Danilov: How important is long-term efficacy and safety data when making informed treatment decisions and how may these data shape your overall treatment approach?
  3. Dr Coombs asks about Frontline use??
    • ELEVATE-TN – 6-yr follow up (Sharman, et al. ASH 2023. Abstract 636)
    • SEQUOIA – Extended Follow-up (Munir, et al. Hemasphere 2023)
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