Association of T-cell subtypes with macrophage-specific arterial infiltration in PWH

Samuel R Schnittman^{1

2}, Ria Talathi², Moses Q Wilks³, Sandeep Hedgire⁴, Michael T Lu⁴, Lindsay T Fourman², David A Alagpulinsa⁵, Sara L Stockman², Kevin S White⁶, Zoey K Wallis⁶, Patrick Autissier⁶, Takara L Stanley², Hang Lee⁷, Michael C Honigberg⁸, Georges El-Fakhri³, Kenneth C Williams⁶, Markella V Zanni², Steven K Grinspoon², Mabel Toribio²

Affiliations

¹ Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
² Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
³ Yale PET Center, Yale School of Medicine, New Haven, CT, USA.
⁴ Cardiovascular Imaging Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
⁵ Yale Center for Molecular and Systems Metabolism & Department of Comparative Medicine, Yale School of Medicine, New Haven, CT, USA.
⁶ Biology Department, Boston College, Chestnut Hill, Massachusetts, USA.
⁷ Biostatistics Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
⁸ Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

PMID: 38905489
DOI: 10.1097/QAD.0000000000003967

Association of T-cell subtypes with macrophage-specific arterial infiltration in PWH

Samuel R Schnittman et al. AIDS. 2024.

. 2024 Jun 21.

doi: 10.1097/QAD.0000000000003967. Online ahead of print.

Authors

Affiliations

¹ Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
² Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
³ Yale PET Center, Yale School of Medicine, New Haven, CT, USA.
⁴ Cardiovascular Imaging Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
⁵ Yale Center for Molecular and Systems Metabolism & Department of Comparative Medicine, Yale School of Medicine, New Haven, CT, USA.
⁶ Biology Department, Boston College, Chestnut Hill, Massachusetts, USA.
⁷ Biostatistics Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
⁸ Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

PMID: 38905489
DOI: 10.1097/QAD.0000000000003967

Abstract

People with human immunodeficiency virus (HIV, PWH) face an increased risk of cardiovascular disease (CVD) compared to the general population. We previously demonstrated that people with (versus without) HIV have higher macrophage-specific arterial infiltration in relation to systemic monocyte activation. We now show that select T lymphocyte subpopulations (naïve CD4+, effector memory CD4+, and central memory CD8+) are differentially associated with macrophage-specific arterial infiltration among participants with versus without HIV, with evidence of interaction by HIV status. Our results suggest that among PWH, circulating T lymphocytes associate with macrophage-specific arterial infiltration, of relevance to atherogenesis and CVD risk.

Clinical trials registration: NCT02542371.

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K08 HL166687/HL/NHLBI NIH HHS/United States

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- NCI CPTC Antibody Characterization Program

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Association of T-cell subtypes with macrophage-specific arterial infiltration in PWH

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Association of T-cell subtypes with macrophage-specific arterial infiltration in PWH

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