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Pathogenesis of neurodevelopmental delays in infants during maternal Zika virus infection is not well understood. Here, the authors show that congenital Zika virus infection in macaques disrupts fetal neurodevelopment through myelin decompaction and suppression of myelin gene expression.
This study shows that a single-stranded RNA phage binds to the Pseudomonas aeruginosa type IV pilus, leading to phage entry into the cell and the detachment of the pilus, which impairs bacterial motility.
Human norovirus infection is a major global health concern, but a suitable animal model is lacking. We have established repeated infection with human norovirus in rhesus macaques via oral challenge. Animals demonstrate virus shedding in the stool and subsequent serum antibody responses, and virus replication is detected in the small intestine.
Recovery and characterization of the wild-type pangolin coronavirus GD strain helps determine whether these viruses present risks for human transmission and an emerging threat to public health.
This study shows that intercellular long extensions promote the evasion of antibody neutralization and the efficient intercellular transmission of chikungunya virus in vitro and in vivo.
This study suggests that pre-existing DENV immunity has a negative effect on the pathogenesis of secondary ZIKV infection during pregnancy in marmosets.