The folding of ribosomal RNAs is central to the biogenesis of the mitoribosome and is a complex, stepwise process. Five recent cryo-EM studies detail the late steps of the folding and maturation of the human mitoribosomal large subunit RNA that forms the catalytic core of the ribosome: the peptidyl transferase center (PTC).
- Marie Sissler
- Yaser Hashem