The Clinical Trials Transformation Initiative (CTTI) provides recommendations to unlock the full potential of digital health trials, including tools to develop digital biomarkers or endpoints, apply remote technology and interact with health authorities.

Many scientific breakthroughs occur when researchers with different expertise come together to work collaboratively, an effort welcomed by the US National Institutes of Health (NIH). This Comment provides the perspective of two program officers from the National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) to help researchers with collaborative projects apply for NIH funding.

Photodynamic therapy allows the local destruction of diseased cells and tissues by light. This Review examines how photodynamic therapy and priming can be engineered for the treatment of localized, regional and distant cancer, from photosensitizer engineering to photonic devices and clinical translation.

Cells can be engineered to modify their function and behaviour for therapeutic and diagnostic applications. This Review discusses biological, genetic and materials-based engineering approaches for both mammalian and bacterial cells, outlining key design strategies and applications of engineered cell products.

The Clinical Trials Transformation Initiative (CTTI) provides recommendations to unlock the full potential of digital health trials, including tools to develop digital biomarkers or endpoints, apply remote technology and interact with health authorities.

Many scientific breakthroughs occur when researchers with different expertise come together to work collaboratively, an effort welcomed by the US National Institutes of Health (NIH). This Comment provides the perspective of two program officers from the National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) to help researchers with collaborative projects apply for NIH funding.

Photodynamic therapy allows the local destruction of diseased cells and tissues by light. This Review examines how photodynamic therapy and priming can be engineered for the treatment of localized, regional and distant cancer, from photosensitizer engineering to photonic devices and clinical translation.

Cells can be engineered to modify their function and behaviour for therapeutic and diagnostic applications. This Review discusses biological, genetic and materials-based engineering approaches for both mammalian and bacterial cells, outlining key design strategies and applications of engineered cell products.

Polysaccharides possess immune-activating or immune-regulatory functions and can thus be applied as immunomodulators. This Review discusses engineering approaches for the design of polysaccharides for vaccine, immunoadjuvant, immune-modulation and drug-delivery applications.

An article in Nature Communications reports a metabolic modelling-based framework to construct synthetic microbiomes that can degrade specific herbicides in soil.

Soft bioelectronic devices are made from polymer-based and hybrid electronic materials that form natural interfaces with the human body. In this Review, the authors present recent developments in soft bioelectronic sensors and actuators, and discuss system-level integration for wearable and implantable medical applications.

Global health-related research and development continues to uphold colonialist structures, concentrating knowledge generation and innovation to high-income countries, thereby hindering global health equity. Therefore, in addition to engineering new technologies, bioengineers will need to try to engineer equitable relationships.

Brain-on-a-chip models, mimicking brain physiology, hold promise for developing treatments for neurological disorders. This Review discusses the engineering challenges and opportunities for these devices, including the integration of 3D cell cultures and electrodes and scaffold engineering strategies.