Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
A correlation spectroscopy technique has been developed for interferometric scattering (iSCAT) microscopy, enabling quantitative measurement of chromatin condensation dynamics in live mammalian cells without requiring any labels.
A diffusion imaging study suggests that individual differences in learning may be selectively predicted by tissue properties of major white matter tracts in the brain. In this study, the left pArc and SLF3 tracts predicted drawing learning in adults.
ATAC-seq analyses across five grasses reveal that chloroplast DNA accessibility varies across regions and genes, and identified putative protein binding footprints that colocalize with known functional elements and are evolutionarily constrained
The authors show that Hog1, the ortholog of mammalian p38 MAPK, is activated during replicative senescence to counteract the increased ROS levels independently of the checkpoint pathway in telomerase-negative Saccharomyces cerevisiae cells.
The freestanding N-methyltransferase, LcsG, catalyzes terminal methylation in the bioactive nonribosomal peptides known as leucinostatins. This rare activity can enhance the antibiotic properties of leucinostatins against pathogens.
This study highlights the circadian regulation of rapid eye movement sleep as a neurophysiological correlate of subtle brain microstructural changes in key brain regions sensitive to aging and involved in sleep-wake regulation.
An EEG study using event segmentation theory found adolescents segment movies into fewer, longer episodes than adults. Differences in neural communication patterns between brain regions explain why younger people perceive the world as moving slower.
The pod is a crucial organ for soybean seed production. One of the HSP70 family genes is associated with pod size regulation mediated by duration of cell proliferation.
In this study, IL-37d has been evidenced to bind lysosomal Rheb and suppress its activation in mTORC1 independent of TSC2. In hepatocyte, IL-37d is responsively decreased by ethanol and the recombinant TAT-rh-IL-37d protein improves alcohol-induced liver disorders via Rheb-mTORC1 axis.
PRMT2 is a key regulator of inflammation in acute myeloid leukemia. PRMT2-deficient cells exhibit a pro-inflammatory profile associated with STAT3 activation.
An AMPK inhibitor accelerates activation of dormant follicles in murine in vitro-cultured ovaries, accompanied with an upregulation of Wnt and FOXO genes, phosphorylation of β-catenin, and successful egg maturation in vitro.
An MEG study in native English speakers on naturalistic speech comprehension suggests that prosodic boundaries enhance the neural encoding of syntactic phrase boundaries.
A multi-omics study on circadian rhythms in mice suggests that ~35% of tissue-specific genes may be influenced by circadian regulation, and these genes are linked to aging and longevity.
This study reveals RARA’s role in inhibiting ferroptosis through the promotion of TXN and PPM1F, offering a potential therapeutic strategy for LUAD treatment by increasing efficacy of ferroptosis inducers or chemotherapy.
Common dietary emulsifiers such as lecithin, sucrose fatty acid esters, carboxymethylcellulose, and mono- and diglycerides can promote metabolic disorders and intestinal microbiota dysbiosis in mice.
Immortalized cell lines and Caenorhabditis elegans are employed to characterize the aggregation properties and toxicity associated with the C-terminal fragment of TDP-43, a gene product implicated in ALS.
The crystal structure of human DPPA3 bound to UHRF1 PHD finger reveals that human DPPA3 binds to UHRF1 in a manner different from mouse DPPA3. This study provides insights into the distinct functions and structure of human and mouse DPPA3 in oocytes and early embryos.
A fast and robust gene set enrichment method that identifies more significant Gene Ontology terms as compared to current methods, freely available as an R package and user-friendly online tool.
A structural MRI study that suggests race-related differences in the cortical thickness of adolescents are partially driven by inequities in exposure to economic resources and discrimination.
An improved pig genome assembly is reported, using single sperm sequencing to reconstruct chromosome haplotypes, and with improved Y chromosome sequence.