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A phylogenetic analysis of Salmonella Typhi isolated from returning travelers to the United Kingdom between 1980 and 1995 suggests that H58 emerged from a chronic carrier in India in 1987 before spreading globally and was already multidrug resistant.
Macrolide esterase EstX can degrade both veterinary and human-use 16-membered ring macrolides. This enzyme is widely distributed among pathogenic species and across 74 countries on 6 continents,with its dissemination likely facilitated by integrons and transposons.
A comprehensive single-cell analysis of clear cell renal cell carcinoma reveals a previously uncharacterized tip-cell like endothelial phenotype and uncovers immunosuppressive clinically relevant targetable interactions in the tumor microenvironment.
A microbiology study on the creation of plasmids for the candidate vaccine chassis Mycoplasma feriruminatoris and its use to study anti-Ig systems. The study also confirms safety of M. feriruminatoris when used in domestic goats.
Functional locus coeruleus (LC) imaging revealed that older adults exhibited increased LC activation compared to younger adults, indicating possible compensatory overactivation of a structurally declining LC in ageing.
RNA-sequencing data from NK-like CD57+ and PD-1+ CD8+ exhausted-like T cell populations linked to beneficial immunotherapy response in autoimmune patients suggest shared clonal relationships with each other and with common precursor populations.
Alternative splicing profiles of human pancreatic islets at single-cell resolution define endocrine cell types and reveal the dysregulated splicing programs in β-cell maturation in type 2 diabetes pathogenesis.
Authors describe the combined ability of low pH, zinc, and insulin to inhibit fibrillation of islet amyloid peptide and find that insulin mediates this effect in two ways.
Individual characteristics tend to over-perform fMRI-based metrics in the prediction of behavioral measures. However, the combination of both metrics can increase predictive accuracy, suggesting that fMRI-based metrics can successfully complement individual characteristics, mainly in large datasets.
An analysis of the phosphate starvation response in Caulobacter crescentus shows that the extracellular and cytoplasmic phosphate concentrations are sensed by different pathways and play distinct regulatory roles in the adaptation of cells to low-phosphate conditions.
Computational modeling and cancer genomics analysis reveal a new scenario of cancer immune evasion owing to negative frequency-dependent selection (NFDS) of neoantigens, which highlights the role of NFDS in predicting immunotherapy response.
Myb-like protein A (MylA) that has two tandem MYB domains is critical for appropriate fungal growth, development, conidial maturation, dormancy, and germination in Aspergillus nidulans.
Single-particle cryo-EM, aided by simulations, of closed and open hub structures of the calcium calmodulin-dependent protein kinase II shows that the intrinsic hub polymorphism, conserved across isoforms, is due to dimer subunit exchange.
The transcriptional identity and developmental programs of the Innate lymphoid cells in human lymph nodes is described, providing an in-depth understanding of ILC-mediated immunity in humans
This study explores the premise of extended – up to 23 weeks – supercooled storage of human red blood cells in modern and traditional hypothermic additive solutions and the impact of antioxidant supplementation, in comparison to hypothermic storage.
Using molecular dynamics simulations on a plant sugar transporter, the authors emphasize the importance of substrate facial recognition in membrane transporter substrate selectivity.
A correlation spectroscopy technique has been developed for interferometric scattering (iSCAT) microscopy, enabling quantitative measurement of chromatin condensation dynamics in live mammalian cells without requiring any labels.
A diffusion imaging study suggests that individual differences in learning may be selectively predicted by tissue properties of major white matter tracts in the brain. In this study, the left pArc and SLF3 tracts predicted drawing learning in adults.
ATAC-seq analyses across five grasses reveal that chloroplast DNA accessibility varies across regions and genes, and identified putative protein binding footprints that colocalize with known functional elements and are evolutionarily constrained
The authors show that Hog1, the ortholog of mammalian p38 MAPK, is activated during replicative senescence to counteract the increased ROS levels independently of the checkpoint pathway in telomerase-negative Saccharomyces cerevisiae cells.