Extended Data Fig. 4: Erythritol increases platelet aggregation responses to submaximal concentrations of agonists.

ADP-stimulated and Thrombin receptor-activating peptide(TRAP)6-stimulated platelet aggregometry responses of human platelet-rich plasma with fixed concentration of erythritol (45 or 90 μM, red) versus normal saline (vehicle, blue). Data in bar graphs are represented as means (±s.d.), and two-sided P values were calculated by Mann Whitney Test (bar graphs) and by 2-way analysis of variance (overall P value is shown for erythritol effect) with Sidák’s post hoc test. Sidák’s adjusted P values for Erythritol 45 μM vs. vehicle: for ADP 2 μM P = 0.01, ADP 3 μM P = 0.005, for erythritol 90 μM vs. vehicle: TRAP6 5 μM: P = 0.0002. Numbers of independent biological replicates (n) are indicated. *P < 0.05, ** P < 0.01, ***P < 0.001.