Extended Data Fig. 1: Polyol metabolites and major adverse cardiovascular events (MACE) in untargeted metabolomics analyses of the discovery cohort.
From: The artificial sweetener erythritol and cardiovascular event risk
Shown are boxplots with relative levels for the indicated polyol (defined as compounds with two or more hydroxyl groups) area in both patients with (red) and without (blue) incident (3 yr) MACE ranked by Mann Whitney P values. Compound relative areas are shown as log of fold change (no MACE vs. MACE) to facilitate comparison. Boxes represent interquartile ranges (IQR) with the notch indicating the median. Lower whiskers represent smallest observation (≥25% quantile -1.5×IQR) and upper whiskers largest observation (≤75% quantile +1.5×IQR). Two-sided P values were calculated by Mann–Whitney U-test. N for no MACE = 1041, n for MACE = 116. False discovery rate corrected two-sided P values (Benjamini-Hochberg method) are indicated as follows: ****P<0.0001, ***P < 0.001, **P < 0.01, *P < 0.05.