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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal��s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Pathogenesis and Potential Treatments of Neurointestinal Diseases

edited by

Jaime Belkind-Gerson

and

Ryo Hotta

submission deadline 31 Jul 2024 | 10 articles | Viewed by 16293

Keywords: enteric nervous system; gastrointestinal motility; enteric neuropathies; neurogenesis; regeneration; brain– gut axis; development

(This special issue belongs to the Section Molecular Medicine)

Stress, Aging and Metabolism

edited by

Myungjin Kim

submission deadline 31 Jul 2024 | 3 articles | Viewed by 10151

Keywords: DNA damage; oxidative stress; aging; lifespan; healthspan; metabolism; stress-induced molecules and their functions; autophagy; exercise; nutritional restriction

(This special issue belongs to the Section Molecular Medicine)

Defects in the Transport Mechanism of Membrane Proteins and Related Diseases

edited by

Daniela Valeria Miniero

submission deadline 31 Jul 2024 | 5 articles | Viewed by 8283

Keywords: function; structure and folding of membrane transport proteins; pathological mutations; mechanism of transport; neurological and metabolic disease; transport of nanoparticles; organelle membranes; cellular function and signaling; bioenergetics; neuroinflammation; nanoformulations for drug targets

(This special issue belongs to the Section Cellular Biochemistry)

The Role of Tumor Microenvironment in the Pathogenesis and Progression of Hematological Malignancies

edited by

Cesarina Giallongo

submission deadline 31 Jul 2024 | 3 articles | Viewed by 7216

Keywords: inflammation; metabolic rewiring; epigenetics; mesenchymal stromal cells; immune cells; immune-escape

(This special issue belongs to the Section Molecular Medicine)

Molecular Research in Uterine Physiology and Pathology

edited by

Paola Viganò

and

Maíra Casalechi

submission deadline 31 Jul 2024 | 3 articles | Viewed by 5452

Keywords: endometrium; myometrium; endometriosis; uterine disorders; uterine molecular alterations; reproduction; implantation; endometrial cancer; uterine fluid; adenomyosis; leiomyoma; endometritis

(This special issue belongs to the Section Molecular Medicine)

NMDA Receptor in Health and Diseases: 2nd Edition

edited by

Motohiro Okada

submission deadline 31 Jul 2024 | 3 articles | Viewed by 5368

(This special issue belongs to the Section Molecular Biology)

Biomarkers in Renal Diseases Ⅱ

edited by

Rosemary Wangensteen

Antonio Osuna Ortega

and

María del Carmen de Gracia Guindo

submission deadline 31 Jul 2024 | 2 articles | Viewed by 4729

Keywords: biomarkers; acute kidney injury; chronic kidney disease; microvesicles; exosomes

(This special issue belongs to the Section Molecular Biomarkers)

H₂S, Polysulfides, and Enzymes: Physiological and Pathological Aspects: 2nd Edition

edited by

Maria Wróbel

and

Halina Jurkowska

submission deadline 31 Jul 2024 | 2 articles | Viewed by 4103

Keywords: H2S and polysulfide; H2S in inflammation; H2S in brain; heart; liver; kidney; and pulmonary diseases; H2S in cancer cells; H2S in the pathogenesis of diabetes; H2S and polysulfides biosynthetic enzymes; H2S precursors

(This special issue belongs to the Section Molecular Medicine)

Mitochondrial Proteins: From Import and Biogenesis to Complex Functional Network

edited by

Venkatesh Sundararajan

submission deadline 31 Jul 2024 | 1 articles | Viewed by 3939

Keywords: mitochondrial proteins; import; biogenesis; metabolism; functional network; oxidative stress; small molecules; mitochondrial protein quality control; mitophagy

(This special issue belongs to the Section Biomacromolecules: Proteins)

Advanced Glycation End-Products (AGEs): Receptors, Signalling Pathways, and Anti-AGE Therapies

edited by Maria Koziołkiewicz and Aleksandra Twarda-Clapa

submission deadline 31 Jul 2024 | 2 articles | Viewed by 3740

Keywords: advanced glycation end-products; AGEs; AGE receptors; anti-AGE therapies; RAGE; scavenger receptors; AGE-related diseases; signalling pathways

(This special issue belongs to the Section Biomacromolecules: Carbohydrates)

Molecular Aspects of Diseases Origin and Development

edited by

Natalia Kurhaluk

submission deadline 31 Jul 2024 | 2 articles | Viewed by 3189

The Genomics Era: From Reference Genomes to Pan-Genomic Approach II

edited by

Chiara Scapoli

submission deadline 31 Jul 2024 | 1 articles | Viewed by 1476

Keywords: pangenome; genome evolution; graph-based pangenome; core and dispensable genomes; human genomics; metagenomics; transcriptome; structural variation

(This special issue belongs to the Section Molecular Genetics)

Recent Advances in the Isolation, Chemical and Biological Characterization and Synthesis of Bioactive Metabolites from Plants

edited by

Antonio Evidente

and

Stefano Superchi

submission deadline 31 Jul 2024 | 1 articles | Viewed by 1306

Keywords: plants; bioactive metabolite; natural analogues; chemical and biological characterization; synthesis; synthetic intermediates and derivatives

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Molecular Mechanisms and Biomedical Applications of Virus Entry

edited by

Vaibhav Tiwari

submission deadline 31 Jul 2024 | 1 articles | Viewed by 888

Keywords: heparan sulfate; virus entry; virus– host cell interactions; virus cell-to-cell fusion

New Insights into Diseases with Cognitive Impairment: Development, Genesis, and Treatment

edited by

Omar Cauli

submission deadline 31 Jul 2024 | Viewed by 342

Keywords: dementia; brain; biomarkers

Natural Products in Chemo- or Hormone Therapy: 2nd Edition

edited by

Piwen Wang

submission deadline 31 Jul 2024 | Viewed by 297

Keywords: natural compounds; chemotherapy; hormone therapy; cancer; phytochemicals; combination

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Advances in Cancer and Glycosylation

edited by

Myron R. Szewczuk

submission deadline 31 Jul 2024 | Viewed by 199

Keywords: glycosylation; glycobiology; N-glycans; O-glycans; glycosyltransferases; glycosidases

(This special issue belongs to the Section Molecular Medicine)

Neurocognitive Disorders: From Molecular Mechanisms to Therapeutic Strategies

edited by Mbemba Jabbi

submission deadline 31 Jul 2024 | Viewed by 191

Keywords: neurocognition; molecular mechanisms; brain anatomy; disease

(This special issue belongs to the Section Molecular Medicine)

Role of the Immune System in Mycobacterial Infection

edited by Auriol Purdie

submission deadline 31 Jul 2024 | Viewed by 191

Keywords: mycobacterial infections; host immune response; livestock species; zoonotic transmission; cross-species dynamics; macrophages; dendritic cells; T lymphocytes; pro-inflammatory signals; anti-inflammatory signals; immunomodulation; host genetic factors; veterinary immunology; animal health; tuberculosis in livestock; Johne’ s disease (Mycobacterium avium subsp. paratuberculosis); bovine tuberculosis (Mycobacterium bovis); avian tuberculosis (Mycobacterium avium); immune evasion mechanisms; comparative immunology; innate immunity; adaptive immunity; one health approach

Role of the ABI1 Gene in Cancers

edited by Leszek Kotula

submission deadline 31 Jul 2024 | Viewed by 154

Keywords: ABI1 cancer EMT cell signaling actin cytoskeleton

(This special issue belongs to the Section Molecular Genetics)

Exploring the Dynamics of Protein Lysine Methylation and Its Implication in Disease

edited by Kyle K. Biggar

submission deadline 1 Aug 2024 | 3 articles | Viewed by 1788 | Submission Open

Keywords: protein regulation; disease mechanisms; biomarkers and therapeutic targets; cellular signaling; mass spectrometry

(This special issue belongs to the Section Biomacromolecules: Proteins)

DNA Methylation in Human Diseases

edited by

Eleonora Loi

Patrizia Zavattari

and

Ana Florencia Vega Benedetti

submission deadline 15 Aug 2024 | 6 articles | Viewed by 10094 | Submission Open

Keywords: DNA methylation alterations; DNA methylation profiling; DNMT aberrations; TET aberrations; DNA methylation machinery; DNA methylation biomarkers; DNA methylation reprogramming

(This special issue belongs to the Section Biomacromolecules: Nucleic Acids)

Extracellular Vesicles as Biomarkers of Diseases

edited by

Mebarek Saida

and

Leyre Brizuela

submission deadline 15 Aug 2024 | 4 articles | Viewed by 6410 | Submission Open

Keywords: extracellular vesicles; metabolic syndrome; cancer; cardiovascular diseases; neurodegenerative diseases; biomarkers

(This special issue belongs to the Section Molecular Biomarkers)

What Is the Weight of Epigenetic Inheritance over Generations?

edited by

and

submission deadline 15 Aug 2024 | 2 articles | Viewed by 4295 | Submission Open

Keywords: genetic; epigenetic; transcripts variation; diseases; model organisms

(This special issue belongs to the Section Molecular Genetics)

The Role of Metals Ions in Neurodegenerative Diseases

edited by Imre Sòvágó

submission deadline 15 Aug 2024 | 1 articles | Viewed by 919 | Submission Open

Keywords: Alzheimer’ s disease; Parkinson’ s disease; metal complexes; amyloid-beta; peptide fragments of prion and tau proteins

The Role of Scaffold Proteins in Human Diseases

edited by László Buday and

Virag Vas

submission deadline 15 Aug 2024 | Viewed by 242 | Submission Open

Keywords: scaffold proteins; cellular signalling; protein– protein interactions; protein domains; human diseases; drug targets; protein complex formation; pathogenic alterations

Mechanisms of Schizophrenia: Insights to Unlock the Brain Puzzle and Generate Effective Antipsychotic Drugs

edited by Tatiana V. Lipina

submission deadline 15 Aug 2024 | Viewed by 48 | Submission Open

Keywords: animal models of schizophrenia; antipsychotic drugs; brain; genes; D2R

Advances in Melanoma Targeted Therapy

edited by

Dmitriy Minond

submission deadline 20 Aug 2024 | 2 articles | Viewed by 4907 | Submission Open

Keywords: melanoma; drug discovery; new targets; target discovery

(This special issue belongs to the Section Molecular Medicine)

Advances in the Molecular Mechanisms of Inflammatory Arthritis and Inflammation-Related Bone Changes

edited by

Michael Schirmer

and

Carlo Perricone

submission deadline 20 Aug 2024 | 2 articles | Viewed by 3474 | Submission Open

Keywords: inflammatory arthritis; molecular mechanisms; bone changes; osteoimmunology; autoimmunity

(This special issue belongs to the Section Molecular Medicine)

Biotechnological and Biomedical Applications of Enzymes Involved in the Synthesis of Nucleosides and Nucleotides—2nd Edition

edited by

Jesús Fernandez Lucas

submission deadline 20 Aug 2024 | 5 articles | Viewed by 3091 | Submission Open

Keywords: biotransformations; biomedicine; enzyme technology; biochemistry; organic chemistry

(This special issue belongs to the Section Enzymology)

Tryptophan-Kynurenine Pathway in Health and Disease

edited by

Tomasz Kocki

and

Ewa M. Urbańska

submission deadline 20 Aug 2024 | 1 articles | Viewed by 974 | Submission Open

Keywords: tryptophan; kynurenine pathway; kynurenic acid; neuropsychiatric disorders; metabolic disorders

(This special issue belongs to the Section Molecular Medicine)

The Role of Microglia in Aging and Neurodegenerative Disease

edited by

Björn Spittau

submission deadline 25 Aug 2024 | 2 articles | Viewed by 1540 | Submission Open

Keywords: microglia; neurodegenerative diseases; disease-associated microglia (DAM); microglia activation; Alzheimer's disease; Parkinson’ s disease; ischemic stroke

(This special issue belongs to the Section Molecular Medicine)

Plant Polyphenols in the Immune and Inflammatory Responses, 2nd Edition

edited by

Heping Cao

submission deadline 25 Aug 2024 | 1 articles | Viewed by 1203 | Submission Open

Keywords: plant polyphenol; bioactivity; immunity; inflammation; molecular mechanism; structure-function relationship

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Role of Thiols in Oxidant-Induced Injuries

edited by

Zacharias Suntres

submission deadline 25 Aug 2024 | Viewed by 250 | Submission Open

Keywords: cysteine; sulfhydryl; thiol; antioxidants; reactive oxygen species; free radicals; oxidant-induced injuries

(This special issue belongs to the Section Molecular Biology)

Wnt Pathway Regulation in Development, Stem Cells and Cancer

edited by Marc De La Roche

submission deadline 25 Aug 2024 | Viewed by 249 | Submission Open

Keywords: Wnt pathway regulation and function; metazoan development; stem cells; Wnt pathway driven cancer

(This special issue belongs to the Section Biological Factors)

Connexins, Pannexins, and Homologous Channel-Forming Proteins

edited by

Mauricio Retamal

and

Juan Carlos Saéz

submission deadline 30 Aug 2024 | 2 articles | Viewed by 3563 | Submission Open

Keywords: gap junctions; hemichannels; connexins; pannexins; innexins; unnexins; paracrine; autocrine

(This special issue belongs to the Section Biomacromolecules: Proteins)

Non-coding RNAs in Human Diseases: Roles and Mechanisms of Action

edited by Lei Jin

submission deadline 30 Aug 2024 | Viewed by 312 | Submission Open

Keywords: non-coding RNAs; human diseases; diagnostic markers; therapeutic targets; prognostic indicators

(This special issue belongs to the Section Molecular Genetics)

Mitochondrial Quality Control in Aging and Neurodegeneration

edited by Sofie Lautrup

submission deadline 31 Aug 2024 | 5 articles | Viewed by 11795 | Submission Open

Keywords: mitochondria; quality control; mitochondrial biogenesis; mitochondrial dynamics; fission; fusion; mitophagy; mitochondrial degradation; cellular metabolism; aging; neurodegeneration; neurodegenerative diseases; Alzheimer’ s disease; Parkinson’ s disease

(This special issue belongs to the Section Cellular Biochemistry)

Advances in Neuroproteomics

edited by

Kenneth R. Williams

and

Angus C. Nairn

submission deadline 31 Aug 2024 | 6 articles | Viewed by 11538 | Submission Open

Keywords: discovery mass spectrometry; neuroproteomics; mass spectrometry; quantitative proteomics; targeted mass spectrometry

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Synuclein Proteins II

edited by

Declan P. McKernan

and

Xiaobo Mao

submission deadline 31 Aug 2024 | 6 articles | Viewed by 10586 | Submission Open

Keywords: synuclein native structures & functions; synuclein genetics; tissue expression and regulation of synucleins; synuclein aggregates; animal models of synucleinopathies; synuclein interacting partners; synuclein and neurotransmission; synuclein and neurodegeneration; synuclein and immune responses

(This special issue belongs to the Section Molecular Biology)

Hormonal Control of Plant Growth and Development

edited by

Nihal Dharmasiri

submission deadline 31 Aug 2024 | 2 articles | Viewed by 3774 | Submission Open

Keywords: plant hormones; auxins; cytokinin; gibberellins; ethylene; abscisic acid; jasmonic acid; salicylic acid; peptide hormones; growth and development

(This special issue belongs to the Section Biological Factors)

Advances in Metabolites Produced by Microbiota

edited by

Arancha Llama-Palacios

submission deadline 31 Aug 2024 | 2 articles | Viewed by 2996 | Submission Open

Keywords: microbiota; metabolites; short-chain fatty acids; amino acids; vitamins

(This special issue belongs to the Section Cellular Biochemistry)

Advances in the Pathology of Prostate Cancer

edited by

Piwen Wang

submission deadline 31 Aug 2024 | 2 articles | Viewed by 2903 | Submission Open

Keywords: prostate cancer; molecular pathology; biomarker; chemoprevention; therapy

(This special issue belongs to the Section Molecular Biology)

New Insight into the Molecular Genetics of Neurodevelopmental Disorders

edited by

Luciana Musante

and Flavio Faletra

submission deadline 31 Aug 2024 | 2 articles | Viewed by 2313 | Submission Open

Keywords: neurodevelopmental disorders; next generation sequencing; pathomechanisms; phenotypic spectra; phenotype-genotype correlation

(This special issue belongs to the Section Molecular Genetics)

The Role of P-type ATPases in Health and Diseases

edited by

Olga Vagin

Sigrid A. Langhans

and

Laura Dada

submission deadline 31 Aug 2024 | 2 articles | Viewed by 2218 | Submission Open

Keywords: P-type ATPases; Na; K-ATPase; H-ATPase; H; K-ATPase; Ca-ATPase; Cu-ATPase; phospholipid flippases; genetic disease

(This special issue belongs to the Section Cellular Biochemistry)

Current Advances in ABC Transporters in Physiology and Disease

edited by

Hiroshi Nakagawa

submission deadline 31 Aug 2024 | 1 articles | Viewed by 2168 | Submission Open

Keywords: functions; structure; regulation; genetic polymorphisms

(This special issue belongs to the Section Molecular Biology)

The Illumination of Biophysical Mechanisms by Hydrogen Exchange: A Themed Issue in Honor of Professor S. Walter Englander

edited by

A. Joshua Wand

submission deadline 31 Aug 2024 | 1 articles | Viewed by 2149 | Submission Open

Keywords: hydrogen exchange chemistry; HX– NMR; HX-MS; protein folding; allostery; protein binding; protein thermodynamics; protein biophysics; protein function

Key Molecules in Traditional Medicine: From Molecular Mechanisms to Therapies Strategies

edited by

Seungtae Kim

and

Sunoh Kwon

submission deadline 31 Aug 2024 | 1 articles | Viewed by 1489 | Submission Open

Keywords: natural compounds; traditional medicine; biomolecules in medicinal herbs; molecular changes caused by traditional medicine treatments

(This special issue belongs to the Section Natural and Bio-derived Molecules)

The Central Role of Mitochondrial Protein VDAC1 in Human Diseases – Honorary Special Issue Commemorating the Work of Prof. Varda Shoshan-Barmatz

edited by Jay H. Chung

submission deadline 31 Aug 2024 | 1 articles | Viewed by 1184 | Submission Open

Keywords: apoptosis; ferroptosis; inflammation; metabolism; mitochondria; oxidative stress; pyroptosis; VDAC; cancer