Patho-Mechanisms Associated with Oral Autoimmune Disease and Cancer
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Medical Biology".
Deadline for manuscript submissions: closed (15 July 2024) | Viewed by 16346
Special Issue Editor
Interests: oral carcinogenesis; autoimmune blistering diseases; cell adhesion
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
I cordially invite you to share your expertise in the field of oral autoimmune diseases and oral cancer by contributing with an original or review article to Biology.
The peculiar morpho-functional characteristics of the oral cavity make it a unique anatomical district. Similarly, the diseases presenting or manifesting in the oral cavity often show distinct pathophysiological features compared to diseases manifesting in other body districts, including a range of autoimmune and neoplastic conditions. Despite the obvious differences, these classes of disease share several mechanistic processes, such as common molecular and functional pathways as well as biomarkers. For example, the tumour microenvironment is a key driver of cancer progression and, similarly, the development of autoimmune diseases involves an intricate network of cytokines and immune cells of the microenvironment. In both pathological processes, the pivotal role of the oral microbiota is being increasingly recognised. In another example, cell adhesion molecules are key to the pathophysiology of oral squamous cell carcinoma but are also the main targets of several oral autoimmune blistering diseases. From a systems biology perspective, we have used oral cancer and oral autoimmune diseases as models of internal and external perturbation of the system, respectively.
The purpose of this Special Issue is to elucidate the pathophysiology of these chronic, life-threatening conditions. An integrated view of the mechanisms maintaining health and disease of the oral cavity will highlight the importance of the molecular determinants of oral health and can provide new models that lay the foundations for translational research.
Prof. Dr. Nicola Cirillo
Guest Editor
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Keywords
- oral cancer
- blistering diseases
- autoimmunity
- cell-adhesion
- microenvironment
