Immuno, Volume 4, Issue 2 (June 2024) – 4 articles
Cover Story (view full-size image):
Resveratrol and its derivative piceid exhibit a wide spectrum of health-promoting bioactivities. Resveratrol-enriched rice, DJ526, has been developed by transfection of a resveratrol biosynthesis gene. These resveratrol-enriched seeds were induced to callus. Callus extract contained greater amounts of resveratrol and piceid than DJ526 seeds, and treatment with DJ526 callus extract significantly reduced the LPS-induced production of proinflammatory mediators. The inflammation-related NF-κB and MAPK pathways were also inhibited in DJ526-callus-extract-treated RAW264.7 cells, resulting in downregulation of proinflammatory factor genes. These finding demonstrate increased resveratrol and piceid content by callus culture of DJ526 rice seeds and the potent anti-inflammatory activity of resveratrol-enriched callus extract. View this paper
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