Non-Coding RNA, Volume 10, Issue 3 (June 2024) – 8 articles
Cover Story (view full-size image):
Transcriptional regulation mediated by the MEF2C transcription factor influences gene expression during early development. Recently, non-coding RNAs, especially microRNAs, have added complexity to our understanding of gene regulation by impacting transcriptional and post-transcriptional processes. MEF2C was found to activate the long regulatory element upstream of the miR-23a-miR-27a-miR-24-2 cluster, affecting mature microRNA levels without altering pri-miRNA expression. These results highlight the dual role of MEF2C in transcriptional activation and post-transcriptional regulation, involving interactions with pre-miRNAs and specific RNA transcripts such as Ksrp, HnRNPa3, and Ddx17, elucidating intricate regulatory mechanisms of gene expression. View this paper
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