Gels, Volume 10, Issue 7 (July 2024) – 70 articles
Cover Story (view full-size image):
A coenzyme A (CoA)-responsive electrochemical sensor was designed using a polyallylamine–manganese oxide–polymer dot nanogel coated on the surface of an electrode to detect various genetic models of osteoarthritis (OA). The CoA-responsive nanogel sensor can respond to the abundance of CoA in OA, causing the breakage of MnO2 in the nanogel, thereby changing the electroconductivity of the sensor. The CoA-responsive nanogel sensor can detect different OA genetic models that contained different levels of CoA (wild type/WT, NudT7 knockout/N7KO, and Acot12 knockout/A12KO), indicated by the increase in resistance depending on the expressed CoA concentration. To simplify its application, the CoA-responsive nanogel sensor was combined with a wireless monitoring device to allow the sensing data to be directly transmitted to a smartphone. View this paper
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