Biomolecules, Volume 14, Issue 6 (June 2024) – 128 articles
Cover Story (view full-size image):
NGF exerts its biological action via tropomyosin receptor kinase A (TrkA), tyrosine kinase activity, and P75 neurotrophic receptors (p75NTR), a transmembrane glycoprotein. All neurotrophins bind to p75NTR but the interaction of NGF with TrkA is specific and its activation leads to the involvement of NGF in several signalling processes such as cell differentiation and survival, growth cessation and neuron apoptosis. The progress of research on NGF and the development of a manufacturing process of a new recombinant human NGF have allowed both the clinical translation of the protein as a novel therapeutic approach to cure a rare ocular disease, and the extension of studies in other fields, such as CNS, thus highlighting that the discovery of NGF represents a significant milestone in neuroscience. View this paper
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