Epigenomes, Volume 8, Issue 2 (June 2024) – 12 articles
Cover Story (view full-size image):
Neuroepithelial cells (NECs) undergo symmetric cell division to produce an initial pool of cortical progenitors that later transform into radial glia cells (RGCs), which act as primary neural stem cells (NSCs). RGCs first produce Cajal-Retzius cells (CRCs), which form the preplate. RGCs next produce deep layer (DL) neurons, and subsequently upper layer (UL) neurons mostly through intermediate progenitor cells (IPCs). In later stages, RGCs acquire the ability to differentiate into glial cells and give rise to astrocytes and oligodendrocytes. During cortical development, the proliferation and differentiation of NSCs are regulated by combinations of spatiotemporally modulated cell-intrinsic epigenetic alterations and extrinsic factors, the disruption of which leads to various brain diseases. View this paper
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