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Can your technology learn fast enough to launch? 🔬🧬🚀 I started my scientific career building incremental improvements to rather well-established…
Can your technology learn fast enough to launch? 🔬🧬🚀 I started my scientific career building incremental improvements to rather well-established…
Liked by Max Schubert
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Quorum’s unique high-throughput platform allows us to move FAST. We’re growing the team to make full use of it’s capabilities, and are excited to…
Quorum’s unique high-throughput platform allows us to move FAST. We’re growing the team to make full use of it’s capabilities, and are excited to…
Liked by Max Schubert
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We hope everyone had a great time celebrating the 4th of July! Last week, Switch Bioworks had the opportunity to meet Congressman Kevin Mullin. After…
We hope everyone had a great time celebrating the 4th of July! Last week, Switch Bioworks had the opportunity to meet Congressman Kevin Mullin. After…
Liked by Max Schubert
Experience & Education
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The Grantham Foundation for the Protection of the Environment
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Licenses & Certifications
Publications
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Recombineering and MAGE
Nature Reviews Methods Primers
In this Primer, we describe recombineering and MAGE, their optimal use, their diverse applications and methods for pairing them with other genetic editing tools. We then look forward to the future of genetic engineering.
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Synthetic auxotrophy remains stable after continuous evolution and in co-culture with mammalian cells
Science Advances
Here, we report automated continuous evolution of a synthetic auxotroph using custom chemostats that supply a decreasing concentration of essential biphenylalanine (BipA). After 100 days of evolution in three separate trials, populations exhibit no observable escape and are capable of normal growth rates at 10-fold lower BipA concentration than the ancestral synthetic auxotroph. We observe containment of bacteria without detrimental effects on HEK293T cells. Overall, our findings reveal that…
Here, we report automated continuous evolution of a synthetic auxotroph using custom chemostats that supply a decreasing concentration of essential biphenylalanine (BipA). After 100 days of evolution in three separate trials, populations exhibit no observable escape and are capable of normal growth rates at 10-fold lower BipA concentration than the ancestral synthetic auxotroph. We observe containment of bacteria without detrimental effects on HEK293T cells. Overall, our findings reveal that synthetic auxotrophy is effective on timescales and in contexts that enable diverse applications.
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High throughput functional variant screens via in-vivo production of single-stranded DNA
PNAS
Development of a pooled, multiplexed tool for genetic screens. Retron elements produce single-stranded DNA inside of bacteria. These DNA are both used to write variants into the genome, and "barcodes" to enable highly multiplexed experiments.
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Method for multiplexed integration of synergistic alleles and metabolic pathways in yeasts via CRISPR-Cas9
Yeast Systems Biology
In the highly tractable yeast S. cerevisiae, CRISPR-Cas can be used to conduct multiple engineering steps in parallel, allowing for engineering of complex metabolic pathways at multiple genomic loci in as little as 1 week.
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High-throughput creation and functional profiling of DNA sequence variant libraries using CRISPR–Cas9 in yeast
Nature Biotechnology
See publicationConstruction and characterization of large genetic variant libraries is essential for understanding genome function, but remains challenging. Here, we introduce a Cas9-based approach for generating pools of mutants with defined genetic alterations (deletions, substitutions, and insertions) with an efficiency of 80–100% in yeast, along with methods for tracking their fitness en masse.
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Genotype Specification Language
ACS Synthetic Biology
Genotype Specification Language (GSL), is a language that facilitates the rapid design of large and complex DNA constructs used to engineer genomes. The language allows facile incorporation of parts from a library of cloned DNA constructs and from the “natural” library of parts in fully sequenced and annotated genomes.
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Efficient Multiplexed Integration of Synergistic Alleles and Metabolic Pathways in Yeasts via CRISPR-Cas
Cell Systems
•A streamlined method for Cas9 guide RNA delivery speeds up genome editing in yeast
•Selection for homologous recombination competency boosts multiplex editing efficiency
•Up to five specific point mutations were introduced in one transformation
•A 24 kb/11 gene muconic acid-synthesis pathway was introduced in one transformationOther authors -
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Measuring ectomycorrhizal fungal dispersal: macroecological patterns driven by microscopic propagules
Molecular Ecology
We use an experimental island biogeographic approach to measure the effects of dispersal limitation on the ecological dynamics of an important group of plant symbionts, ectomycorrhizal fungi. We manipulated the isolation of uncolonized host seedlings across a natural landscape and used a range of molecular techniques to measure the dispersal rates of ectomycorrhizal propagules and host colonization.
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Patents
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METHOD OF RECORDING MULTIPLEXED BIOLOGICAL INFORMATION INTO A CRISPR ARRAY USING A RETRON
Filed US WO/2018/191525
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Library-scale engineering of metabolic pathways
Filed US 62/348,438
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Methods for Genomic Integration
Filed US 20150184199
Additional methods for multiplex genome integration using designer nucleases.
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Honors & Awards
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Fifty 50
Fifty Years VC
Fifty 50 is a community of 50 top researchers interested in entrepreneurship, across North America.
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Winner, Climate Change Grant
Harvard Consortium for Space Genetics
$250,000 funding prize for proposed research project with potential to impact Climate Change
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National Defense Science and Engineering Graduate Fellowship (NDSEG)
American Society for Engineering Education, United States Department of Defense
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Honorable Mention, NSF Graduate Research Fellowships Program 2016
National Science Foundation
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2015 DARPA "Riser"
DARPA
One of 53 participants selected from ~300 nominees to present a research proposal at the DARPA "Wait, What?" conference.
More activity by Max
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Drying without Dying: A path to improved sustainable building materials by enhancing cyanobacteria desiccation tolerance. Cement is the most popular…
Drying without Dying: A path to improved sustainable building materials by enhancing cyanobacteria desiccation tolerance. Cement is the most popular…
Liked by Max Schubert
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I'll be giving a brief talk at Carbonauts Sustainability Cocktails on July 10th at Zeitgeist at 6pm - come stop by to network + learn about what I've…
I'll be giving a brief talk at Carbonauts Sustainability Cocktails on July 10th at Zeitgeist at 6pm - come stop by to network + learn about what I've…
Liked by Max Schubert
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Non-Model Organisms Expand the Repertoire of Synthetic Biology I’m happy to share this new SynBioBeta Insights Article by Sachin Rawat, which…
Non-Model Organisms Expand the Repertoire of Synthetic Biology I’m happy to share this new SynBioBeta Insights Article by Sachin Rawat, which…
Liked by Max Schubert
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Exciting Opportunity Alert! Meet ALVARO JOSE SANCHEZ MARTINEZ , our talented microalgae scientist from Spain, who has a passion for both research…
Exciting Opportunity Alert! Meet ALVARO JOSE SANCHEZ MARTINEZ , our talented microalgae scientist from Spain, who has a passion for both research…
Liked by Max Schubert
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Hosting drinks with Sam Levin July 17 in NYC: Are you working in synthetic biology or biotech? Are you bio-adjacent? Peripherally interested in…
Hosting drinks with Sam Levin July 17 in NYC: Are you working in synthetic biology or biotech? Are you bio-adjacent? Peripherally interested in…
Liked by Max Schubert
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I am very excited about the potential agricultural, ecological and climatic impacts of this venture-creation opportunity at Deep Science Ventures…
I am very excited about the potential agricultural, ecological and climatic impacts of this venture-creation opportunity at Deep Science Ventures…
Liked by Max Schubert
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Excited for our new paper out in PNAS today! Take a look https://lnkd.in/ggqBtdt2
Excited for our new paper out in PNAS today! Take a look https://lnkd.in/ggqBtdt2
Liked by Max Schubert
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ReGen Ventures is thrilled to lead Foray Bioscience’s $3 million seed round with participation from Superorganism, The Engine, Susquehanna…
ReGen Ventures is thrilled to lead Foray Bioscience’s $3 million seed round with participation from Superorganism, The Engine, Susquehanna…
Liked by Max Schubert
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Come join Astera as we rebuild the machinery of science for the AI era! At Astera, we believe we're on the brink of a radical shift toward advanced…
Come join Astera as we rebuild the machinery of science for the AI era! At Astera, we believe we're on the brink of a radical shift toward advanced…
Liked by Max Schubert
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Eggplants trees were created through crossbreeding wild species. This looks surreal!
Eggplants trees were created through crossbreeding wild species. This looks surreal!
Liked by Max Schubert
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Deep tech founders: submit your pitch decks to Deep Checks! A ton of deep tech investors and I have been really impressed by the quality of startups…
Deep tech founders: submit your pitch decks to Deep Checks! A ton of deep tech investors and I have been really impressed by the quality of startups…
Liked by Max Schubert
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It’s finally just about almost here: Plonts, a plant-based cheese made from real plonts. Coming to restaurants near you, unless you live in places…
It’s finally just about almost here: Plonts, a plant-based cheese made from real plonts. Coming to restaurants near you, unless you live in places…
Liked by Max Schubert
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I'm excited to share that I have recently started as a Senior Advisor at the newly established U.S. Artificial Intelligence Safety Institute (AISI)…
I'm excited to share that I have recently started as a Senior Advisor at the newly established U.S. Artificial Intelligence Safety Institute (AISI)…
Liked by Max Schubert
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If you think plant-based burgers are healthier for you than beef burgers, you are absolutely and without question RIGHT. And if you think otherwise,…
If you think plant-based burgers are healthier for you than beef burgers, you are absolutely and without question RIGHT. And if you think otherwise,…
Liked by Max Schubert
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