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Articles by Leith
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Comfort in My Own Skin: Taking a Leap of Faith
Comfort in My Own Skin: Taking a Leap of Faith
By Leith States, MD, MPH, MBA FACPM
Activity
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Today on PHRME, hear how Centers for Disease Control and Prevention (CDC)-funded Implementation Centers will assist with public health data…
Today on PHRME, hear how Centers for Disease Control and Prevention (CDC)-funded Implementation Centers will assist with public health data…
Liked by Leith States, MD, MPH, MBA FACPM
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Capt. Marion Gregg, commander of Navy and Marine Corps Force Health Protection Command (NMCFHPC), director of Defense Centers for Public Health –…
Capt. Marion Gregg, commander of Navy and Marine Corps Force Health Protection Command (NMCFHPC), director of Defense Centers for Public Health –…
Liked by Leith States, MD, MPH, MBA FACPM
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It is a new era for the U.S. Army Medical Research and Development Command as MG Paula Lodi has officially assumed command of MRDC. She was…
It is a new era for the U.S. Army Medical Research and Development Command as MG Paula Lodi has officially assumed command of MRDC. She was…
Liked by Leith States, MD, MPH, MBA FACPM
Experience & Education
Licenses & Certifications
Publications
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Report of the Pathogenesis and Pathophysiology of Lyme Disease Subcommittee of the HHS Tick Borne Disease Working Group
Frontiers in Medicine
An understanding of the pathogenesis and pathophysiology of Lyme disease is key to the ultimate care of patients with Lyme disease. To better understand the various mechanisms underlying the infection caused by Borrelia burgdorferi, the Pathogenesis and Pathophysiology of Lyme Disease Subcommittee was formed to review what is currently known about the pathogenesis and pathophysiology of Lyme disease, from its inception, but also especially about its ability to persist in the host. To that end…
An understanding of the pathogenesis and pathophysiology of Lyme disease is key to the ultimate care of patients with Lyme disease. To better understand the various mechanisms underlying the infection caused by Borrelia burgdorferi, the Pathogenesis and Pathophysiology of Lyme Disease Subcommittee was formed to review what is currently known about the pathogenesis and pathophysiology of Lyme disease, from its inception, but also especially about its ability to persist in the host. To that end, the authors of this report were assembled to update our knowledge about the infectious process, identify the gaps that exist in our understanding of the process, and provide recommendations as to how to best approach solutions that could lead to a better means to manage patients with persistent Lyme disease.
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The National Vector-Borne Disease Framework and LymeX Innovation Updates”. Department of Health and Human Services
Department of Health and Human Services
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Addressing Inequities in Older Adults’ Health: A Role for Emerging Technologies
JAMA Health Forum: Insights
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LymeX: Applying Health+ for Patient-Powered Innovations
Department of Health and Human Services
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HHS Leverages Public Feedback to Advance Landscape Analysis on Emerging Technologies for Aging, Underserved Populations
Department of Health and Human Services
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GLI1 Is a Central Mediator of EWS/FLI1 Signaling in Ewing Tumors
PLOS One
AbstractThe Ewing Sarcoma Family Tumors (ESFT) consist of the classical pathologic entities of Ewing Sarcoma and peripheral Primitive Neuroectodermal Tumor. Occurring largely in the childhood through young adult years, these tumors have an unsurpassed propensity for metastasis and have no defined cell of origin. The biology of these aggressive malignancies centers around EWS/FLI1 and related EWS/ETS chimeric transcription factors, which are largely limited to this tumor class. Much progress has…
AbstractThe Ewing Sarcoma Family Tumors (ESFT) consist of the classical pathologic entities of Ewing Sarcoma and peripheral Primitive Neuroectodermal Tumor. Occurring largely in the childhood through young adult years, these tumors have an unsurpassed propensity for metastasis and have no defined cell of origin. The biology of these aggressive malignancies centers around EWS/FLI1 and related EWS/ETS chimeric transcription factors, which are largely limited to this tumor class. Much progress has been made in the identification of a network of loci whose expression is modulated by EWS/FLI1 and its congeners. To date, little progress has been made in reconstructing the sequence of direct and indirect events that produce this network of modulated loci. The recent identification of GLI1 as an upregulated target of EWS/ETS transcription factors suggests a target which may be a more central mediator in the ESFT signaling network. In this paper, we further define the relationship of EWS/FLI1 expression and GLI1 upregulation in ESFT. This relationship is supported with data from primary tumor specimens. It is consistently observed across multiple ESFT cell lines and with multiple means of EWS/FLI1 inhibition. GLI1 inhibition affects tumor cell line phenotype whether shRNA or endogenous or pharmacologic inhibitors are employed. As is seen in model transformation systems, GLI1 upregulation by EWS/FLI1 appears to be independent of Hedgehog stimulation. Consistent with a more central role in ESFT pathogenesis, several known EWS/FLI1 targets appear to be targeted through GLI1. These findings further establish a central role for GLI1 in the pathogenesis of Ewing Tumors.
More activity by Leith
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There are 150,000 dog tags on this memorial. That is one dog tag for every veteran that has taken their own lives since 2001. The status quo must…
There are 150,000 dog tags on this memorial. That is one dog tag for every veteran that has taken their own lives since 2001. The status quo must…
Liked by Leith States, MD, MPH, MBA FACPM
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Upcoming webinar for providers of all types operating in behavioral healthcare settings. Please share in your networks. The Substance Abuse and…
Upcoming webinar for providers of all types operating in behavioral healthcare settings. Please share in your networks. The Substance Abuse and…
Shared by Leith States, MD, MPH, MBA FACPM
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Today, I had the honor of standing alongside heroes and friends, advocating for the FDA to follow the science and approve MDMA-assisted therapy for…
Today, I had the honor of standing alongside heroes and friends, advocating for the FDA to follow the science and approve MDMA-assisted therapy for…
Liked by Leith States, MD, MPH, MBA FACPM
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I'll be attending the amazing 2024 VHA Innovation Experience: Collaborating for Change. Let me know if you're planning to attend so that we can say…
I'll be attending the amazing 2024 VHA Innovation Experience: Collaborating for Change. Let me know if you're planning to attend so that we can say…
Liked by Leith States, MD, MPH, MBA FACPM
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California is in line for more than $4 billion in opioid settlement funds, most of which is and will be controlled by counties and cities. Those…
California is in line for more than $4 billion in opioid settlement funds, most of which is and will be controlled by counties and cities. Those…
Liked by Leith States, MD, MPH, MBA FACPM
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SO much important work here to highlight - but will start with incorporating lessons learned from the CMS Innovation Center primary care models into…
SO much important work here to highlight - but will start with incorporating lessons learned from the CMS Innovation Center primary care models into…
Liked by Leith States, MD, MPH, MBA FACPM
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