Kimberly Norman, PhD, DABT, ERT

The 2024 Summer Olympic Games: Mass Spectrometry's New Role in Sports and Understanding the Athlete's Exposome A newly published study highlights the continuous advancements in mass spectrometry for anti-doping efforts in sports. Researchers emphasize the necessity of differentiating between deliberate doping and inadvertent exposure due to environmental factors, shaping a new era of doping control monitoring. https://lnkd.in/gbdwv7EK

5

Despite numerous optimizations in peptide synthesis, the formation of aspartimide remains a significant side reaction that needs to be addressed. An innovative approach that utilizes hydrazide as a carboxylic-acid-protecting group to reduce the formation of aspartimide. The aspartic acid hydrazide effectively suppresses the formation of aspartimide, even under microwave conditions, and is readily converted to native aspartic acid using CuSO4 in an aqueous medium. https://lnkd.in/g7CERf7Y

28

For combination products, the journey to regulatory approval can be full of unexpected detours. At the Combination Products Summit, Sandi Schaible, Senior Director of Analytical Chemistry & Toxicology, is going to describe the regulatory landscape so you can develop a test plan that gets you to your destination on time! She will walk through: • Why understanding the primary mode of action is important • How a pre-submission meeting can set you on a clear path • The differences between USP and ISO methods Plus, she will share a combination product case study, full of lessons learned from the journey. Don’t miss this insightful discussion! 🗓️ May 3 ⏰ 1:10 PM Find out more: https://hubs.ly/Q02vz_0d0

9

Could your manicure 💅 or handcare 🧼 routine affect forensic evidence? 🔬 Scientists in Japan used microsegmental analysis and LC-MS/MS to investigate how cosmetics, hand care, and environmental factors impact drug stability within fingernails. This has major implications for forensic toxicology and drug monitoring. #forensictoxicology #innovation #science #druganalysis #research #LCMSMS https://lnkd.in/eDC3BPPj

4

📢 #Nanomaterials Volume 14, Issue 8 is freely available to access, read and download. 🔗 Check out all published papers here: https://lnkd.in/eB2qduTi Cover Story: Physiochemical Characterization of Lipidic Nanoformulations Encapsulating the Antifungal Drug Natamycin Keywords: #natamycin; lipid #nanoparticles; #encapsulation; supramolecular; NMR; SAXS

2

At the upcoming Process Development for Highly Potent Drugs Summit in Philadelphia, PA, June 25 - 27, Dec Group CST Director Andrew Lemaire will give insight on navigating the challenges in integrating off-the-shelf lab scale equipment with containment technology in a high containment HPAPI kilo lab & production development scale plant. In this lecture, he will discuss the various considerations that need to be made when integrating equipment and the potential risks of exposure that come with it. He will explore the completion of a 10 isolator OEB6 development scale plant. The challenges faced during this project will be analyzed, along with the strategies used to overcome them. By presenting this case study, we hope to provide valuable insights into the best practices for equipment integration. Join us for this engaging and informative lecture and learn from real-world examples to gain valuable knowledge that can help you navigate similar challenges in your own projects. 👉 Event website: https://hpapi-summit.com/ #decgroup #hpapisummit #highcontainment #processintegration #processisolation #hpapi

75

A PROTAC, prepared over 100 g, simply awe struck to see it done without any preparative or chiral HPLC purifications In particular, captivated to see T3P-mediated coupling of hydroxyproline benzyl ester and N-Boc tert-leucine followed by capping with 1-fluorocyclopropancarboxylic acid and ester hydrolysis to afford that dipeptide fragment. When it's T3P it has to be from Curia

132

More is less when it comes to E3 ligases and there remains a need to expand the repertoire of viable E3 ligases for hijacking. A new set of covalent PROTACs that enables DCAF11-dependent degradation, featuring a cyanoacrylamide warhead. The findings underscore DCAF11 as an interesting candidate with a capacity to accommodate diverse electrophilic chemistries compatible with targeted protein degradation. https://lnkd.in/gW7bWV9W

55

USP’s work on nitrosamine impurities in pharmaceuticals is making headlines, with an interview with Principal Scientist Naiffer Romero being featured in the May 2024 issue of Separation Science. “In a recent discussion with Separation Science, Romero highlighted USP's comprehensive approach to nitrosamine contamination, including the collaborative creation of General Chapter <1469> and the dynamic Nitrosamines Exchange platform. These initiatives, alongside predictive tools, [mitigation mechanisms, and research] underscore USP's proactive role in addressing current and future risks in pharmaceutical safety.” Read more about our initiatives, including contributions to original research from USP experts, the Exchange, our pharmaceutical analytical impurities reference materials, and more in an interview with Naiffer in “Knowledge Sharing as a Tool: USP’s Role in the Global Nitrosamine Battle.” ➡️: https://ow.ly/IjBY50RzqLh

133

3 Comments

A protein-​based gel, packed with whey, iron and gold breaks down alcohol quickly, efficiently and directly in the intestinal tract without harming the body following a multi-​stage cascade of enzymatic reactions that ultimately converts alcohol into harmless acetic acid before it enters the bloodstream The gel shifts the breakdown of alcohol from the liver to the digestive tract. In contrast to when alcohol is metabolised in the liver, no harmful acetaldehyde is produced as an intermediate product. Though it's healthier not to drink alcohol at all. However for the most who don't wish to give up alcohol completely while not straining their bodies as well, the gel could offer the solution, but the catch for the gel to be working is that it would need to be taken orally before or during alcohol consumption until the time it doesn't cross into the bloodstream. https://lnkd.in/guYK5bs4

13

Understanding the role of toxic amyloid precursor protein (APP), called APP-CTFs could open avenues for early intervention therapies that could stop or even prevent Alzheimer's disease. It's the excess of fragments of APP-CTFs, that can trigger a mechanism that occurs at the early stages of Alzheimer's disease. Study shows that amyloid-β and APP-CTF can accumulate in tandem with one another, but researchers have largely overlooked this.‘This knowledge can lead to a smarter drug design that both prevents the accumulation of toxic amyloid-β peptides and APP-CTFs,’ These could include γ-secretase modulators that stabilise – rather than turn off – the activity of γ-secretase, making shorter, non-toxic amyloids, and may prevent APP-CTF accumulation. https://lnkd.in/g5kPS5_A

9

Biological Chemistry MSc Seminar: Come hear Gary Zheng discuss Developing light-switchable affibody based inhibitors of key interactions in the p53 network. June 21st at 2:00 p.m. To learn more, check: https://lnkd.in/g83TEyZA

2

Bio-Rad Laboratories announced the launch of three new StarBright™ Red Dyes StarBright Red 715, 775, and 815 and an expansion of its StarBright Violet Dye series with 29 additional highly validated antibodies conjugated to StarBright Violet 570, 515, 440, 670, 790, and 475 Dyes. Now totaling 32 dyes spanning multiple lasers, Bio-Rad’s range of StarBright Dyes expands translational and immunological research capabilities by providing greater choice and flexibility in conventional and full-spectrum multicolor flow cytometry panels. Read More: https://lnkd.in/dZuVwjnc “The Bio-Rad StarBright Dye portfolio, now totaling 32 dyes across the 355, 405, 488, 561, and 640 nm lasers, is the most comprehensive series of dyes designed specifically for conventional and full-spectrum flow cytometry, and offers superior alternatives to existing dyes,” said Hilary Mavor, Marketing Director, Life Science Group, Bio-Rad. “By continuing to expand our existing portfolio of antibody markers, including new human, mouse, dog, cow, and pig targets, we can offer our customers greater choice and flexibility when building multicolor panels in conventional and full-spectrum flow cytometry.” #mededgemea #BioRad #laboratory #science #research #biology #chemistry #biotechnology #biochemistry #STEM #education #meded #medicaleducation #lifesciences #labtech #BioTech #scientificresearch #lablife #microscopy #experimentation

9

A systems toxicology approach for identification of disruptions in cholesterol homeostasis after aggregated exposure to mixtures of perfluorinated compounds (PFAS) in humans. #TNO #PFAS #PFOS #PFOA https://lnkd.in/ewjzQc3K

2

🍆 DNA Diagnostics Center partners with Contraline in ADAM male contraceptive device trial Contraline is a Virginia-based medical device focused on reproductive health. DNA Diagnostics Center, on the other hand, is part of Eurofins laboratories’ global network. It offers DNA and personal health testing solutions. According to Contraline, ADAM is the world’s first hydrogel designed to offer men a long-lasting, non-hormonal, and reversible contraceptive option. Read more online: https://lnkd.in/gMj_wTmg 📰 Follow Medical Device Developments to receive the latest medical device news daily and to subscribe to our weekly newsletter #MedicalDeviceDevelopments #medicaldevices #medicalmanufacturing

16