About
Experience & Education
Publications
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Changes in resting functional connectivity during abstinence in stimulant use disorder: a preliminary comparison of relapsers and abstainers.
Drug and Alcohol Dependence
Background
Previously identified resting functional connectivity (FC) differences in individuals with stimulant use disorder (SUD) suggest an imbalance in neural regions that mediate behavioral aspects relevant to addiction such as emotion regulation and reward processing. There is a need to further investigate these differences across time between those that relapse and those that do not. This is the first longitudinal study of recently abstinent SUD (SUD-RA) that identifies specific FC…Background
Previously identified resting functional connectivity (FC) differences in individuals with stimulant use disorder (SUD) suggest an imbalance in neural regions that mediate behavioral aspects relevant to addiction such as emotion regulation and reward processing. There is a need to further investigate these differences across time between those that relapse and those that do not. This is the first longitudinal study of recently abstinent SUD (SUD-RA) that identifies specific FC changes in subsequent relapsers (vs abstainers). We hypothesized that (1) subsequent relapsers (vs abstainers) will show lower FC of emotion regulation regions and higher FC of reward processing regions and (2) FC differences would be more evident across time.
Methods
We examined resting FC in 18 SUD-RAs (8 females, age: M = 22.05 ± 2.64) and 15 non-substance abusing controls (NSAC; 5 females, age: M = 24.21 ± 5.76) at Time 1 (abstinent ∼5 weeks). Fourteen NSAC and 12 SUD-RAs were re-examined at Time 2 (abstinent ∼13 weeks). With seed-based FC measures, we examined FC differences between SUD-RAs that abstained or relapsed over the subsequent 6 months.
Results
Relapsers (vs abstainers) had higher FC between (1) nucleus accumbens (NAcc) and left frontopolar cortex (FPC), (2) NAcc and posterior cingulate gyrus and (3) subgenual anterior cingulate and left FPC at Time 1. Relapsers (vs abstainers) showed larger reduction in FC strength within these regions across time.
Conclusions
Resting FC reduction found in relapsers (vs. abstainers) from 5 to 13 weeks of abstinence may be a biological marker of relapse vulnerability. These preliminary findings require replication with larger sample sizes.Other authors -
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Altered resting state complexity in schizophrenia.
NeuroImage
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Comparison of Large-Scale Human Brain Functional and Anatomical Networks in Schizophrenia
In Submission
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Enhancing Cognitive Control Using Transcranial Direct Current Stimulation
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Frontal Hyperconnectivity Related to Discounting and Reversal Learning in Cocaine Subjects.
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Nintendo Wii Balance Board is sensitive to effects of visual tasks on standing sway in healthy elderly adults.
Gait and Posture
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Node analysis of diffusion weighted imaging in schizophrenia.
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Objective Measurement of Postural Sway In Blast-Related Traumatic Brain Injury.
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Overlapping Differences in Anatomical and Functional Networks in Schizophrenia.
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Postural Sway Abnormalities In Chronic Schizophrenia.
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Sensitivity of a low-cost balance platform for the assessment of postural instability.
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