Institute for Protein Design, University of Washington

Welcome to the #100DaysMission Science and Technology Expert Group, Lynda Stuart MD PhD! 🌐 Lynda is a physician-scientist with over 20 years of experience in immunology, global health, and product development. She is an advocate for using the most cutting-edge technologies to solve global health and other societal challenges. As the Executive Director of the Institute for Protein Design, University of Washington, she oversees translational research, institute operations, and corporate and foundation collaborations. The IPD’s mission is to use computational and #AI approaches to create proteins that solve modern challenges in medicine, technology, and sustainability. Find out more about our STEG members: https://lnkd.in/dyc67B_T

Exciting opportunity now available for current University of Washington undergraduates for a position at the Institute for Protein Design, University of Washington! We are seeking a part-time student assistant majoring in either #biochemistry, #immunology, #microbiology, or something similar, who is eager to gain hands-on experience in #electronmicroscopy! University of Washington undergraduates only! Application can be found on 🤝 UW Handshake, Ref 9005157 🤝 Details below! 🌟 Join the Institute for Protein Design! 🌟 About Us: The Institute for Protein Design, University of Washington is at the forefront of creating new proteins to address 21st-century challenges in medicine, energy, and technology. Our diverse team thrives on the exceptional contributions of undergraduate students who support our wet-lab operations. Learn more about us: https://www.ipd.uw.edu/ 👩🔬 DUTIES AND RESPONSIBILITIES 👨🔬 ✨ Facility Maintenance ✨ - Assist with daily maintenance and cleaning of electron microscopy equipment. - Monitor and replenish supplies. - Maintain cleanliness and organization of the microscopy suite. - Assist in waste disposal following safety protocols. 🔬 Negative Stain Imaging 🔬 - Prepare biological samples for negative stain electron microscopy. - Operate electron microscopy equipment under supervision. - Prepare reagents and staining solutions. - Assist in data collection and initial image processing. 📝 Administrative Duties 📝 - Maintain accurate records of sample preparation and imaging sessions. - Help update SOPs and facility documentation. 📔 Safety and Compliance 📔 - Follow all laboratory safety guidelines and protocols. - Participate in safety training sessions and report hazards. 🏫 Minimum Qualifications 🏫 - Current UW undergraduate with an interest in biochemistry, with at least 1-2 years left. - Able to commit at least 12-15 hours per week, depending on lab demands. - Science major and completion/concurrent enrollment in biochemistry strongly preferred. - Basic understanding of laboratory techniques and safety practices. - Strong attention to detail and organizational skills. - Excellent communication skills and ability to work collaboratively in a team environment. - Willingness to learn and adapt to new techniques and technologies. - Previous laboratory experience, particularly in a microscopy or imaging setting, is a plus but not required. - Familiarity with electron microscopy theory and application is advantageous but not required. 🎓 Educational Benefits 🎓 - Hands-on experience with advanced electron microscopy techniques. - Opportunity to work in a collaborative research environment. - Flexible working hours to accommodate academic schedules. - Potential for academic lab course credit.

I am very excited to share a new preprint where we entirely de novo #designed proteins that are able to neutralise 🐍 #snake #venom #toxins in vivo. 📎 You can find the preprint here: https://lnkd.in/dzF-pyDN This is the result of a #collaboration with an amazing group of people. I want to particularly thank Susana Vazquez Torres and David Baker for their commitment to this project! However, many more brilliant scientists were key to this project's success: Melisa Benard Valle, PhD, Stephen Mackessy, Stefanie Menzies, Nicholas Casewell, Shirin Ahmadi, Nick J. B., Edin Muratspahic, Isaac Sappington, Max Overath, Esperanza Rivera de Torre, Jann Ledergerber, Andreas Laustsen-Kiel, Kim Boddum, Asim Bera, Alex Kang, Evans Brackenbrough, Iara Aimê Cardoso, Edouard Crittenden, Rebecca Edge, Justin Decarreau, Robert Ragotte, Arvind Pillai, mohamad abedi, Hannah Han, Stacey Gerben, Analisa Murray, Rebecca Skotheim, Lynda Stuart MD PhD, Lance Stewart, and Thomas Fryer. It's amazing what can be done over the course of a year when you effectively collaborate across institutions (DTU Bioengineering, University of Washington, University of Northern Colorado, Liverpool School of Tropical Medicine, Massachusetts Institute of Technology), disciplines, and countries. 🌍🔬 It's incredible how #biologics discovery has been revolutionised by #AI tools such as #RFdiffusion. 🤖 Being able to detect high affinity, epitope specific, stable, and neutralising binders out of 100 or less tested designs, given nothing more than a target structure is game changing (we demonstrate that both experimental or AF2 predictions can work). This is just the first step towards unlocking the full potential that #generativeAI brings to therapeutics and in particular #neglected #diseases such as #snakebite. 🧬💉 Institute for Protein Design, University of Washington, DTU - Technical University of Denmark