We are excited to share the news that one of our founders, Nils-Goran Larsson, MD, PhD, published a seminal study this week in Nature Metabolism on a potential new approach for treating obesity and metabolic diseases. Larsson and his team at the Department of Medical Biochemistry and Biophysics at Karolinska Institutet found that by inhibiting transcription in mitochondria (the "powerhouse of the cell") with small molecules in a mouse diet-induced obesity model – they could alter liver metabolism directly, encouraging the body to burn fat without the adverse effects on muscle mass as seen with GLP-1 drugs. Overcoming this issue is critical for developing the next generation of weight loss medications. While this research is still in its early days, we are encouraged to continue seeing the potential promise our approach of targeting mitochondria can bring to helping patients. To read the full study, "Inhibition of mammalian mtDNA transcription acts paradoxically to reverse diet-induced hepatosteatosis and obesity" follow this link: https://lnkd.in/ghtJ8Pzt #obesity #obesityresearch #metabolicdisease
Pretzel Therapeutics
Biotechnology Research
Boston, MA 3,003 followers
Welcome to a new era in mitochondrial therapeutics
About us
Our mission is to develop groundbreaking therapies to reverse mitochondrial dysfunction by leveraging a deep mechanistic understanding of mitochondrial biology. Mitochondria are essential energy-converting cellular organelles found in nearly every cell type throughout the body. Dysfunctional mitochondria are involved in more than 50 diseases. The most severe of these are broadly termed mitochondrial diseases, a group of rare genetic conditions which affect individuals of all ages. Mitochondrial dysfunction also plays an important role in more common diseases, including aging-related disorders. At Pretzel, we are developing first-in-class therapeutics that can address mitochondrial dysfunction at its roots. By taking aim at the genetic drivers of mitochondrial dysfunction, we believe our approach could be effective across a wide range of diseases which lack meaningful treatment options today.
- Website
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https://www.pretzeltx.com
External link for Pretzel Therapeutics
- Industry
- Biotechnology Research
- Company size
- 11-50 employees
- Headquarters
- Boston, MA
- Type
- Privately Held
Locations
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Primary
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Boston, MA, US
Employees at Pretzel Therapeutics
Updates
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Read about how Pretzel is bridging innovation and collaboration to help patients with mitochondrial disease:
Meet our community. In September this year, Sweden and US-based biotech start-up company Pretzel Therapeutics moved into its new office and lab space at GoCo House. Read the full article from when we sat down with Pretzel’s Senior Vice President and Head of Biology, Thomas A. Keating, to talk about Pretzel’s work on rare mitochondrial diseases, novel biology, and what is needed for successful collaboration. #collaboration #innovation #gocohic #lifescience