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Fans have been given another sneak peek of Demi Moore and Margaret Qualley's new body horror film, The Substance.
The official teaser for the thriller dropped Thursday and captures aging celebrity fitness instructor Elisabeth Sparkle (played by Demi, 61) after she takes an experimental substance intended to transform her into a younger and improved version of herself.
Qualley, 29, plays Sue, the young woman Elisabeth metamorphosis into.
'A fading celebrity decides to use a black market drug, a cell-replicating substance that temporarily creates a younger, better version of herself,' the IMDb synopsis reads.
The latest sneak peek captures the gruesome aftermath of the injection - as well as some violent consequences that include a terrible car crash Elisabeth gets into.
The first official teaser for Demi Moore and Margaret Qualley's new film The Substance has been released
The film sees Moore's character transforming into a younger version of herself (played by Qualley)
The teaser begins with Elisabeth, gazing at herself in the mirror with her mascara smeared and a crestfallen look on her face.
'Have you ever dreamed of a better version of yourself?' the teaser's narrator asks.
As Qualley's body appears on screen, the narrator continues, 'Younger. More beautiful. More perfect.'
The teaser then captures Sue injecting the neon green liquid into her upper thigh before the painful transformation begins.
She writhes and cries out on the bathroom floor before curling up into a ball beneath the shower.
Throughout the trailer, Sue is shown turning heads as she walks in the sunshine in a flirty look - before filming her fitness show in a skimpy, metallic leotard.
But Sparkle's decision seems to come with some sequences - she is shown getting into a car crash before being flung back into her home.
Sue seems to somehow be involved in the crash - she is shown with blood on her face just before the collision occurs.
Dennis Quaid, who plays studio head Harvey, dons a flashy orange suit as a team of smiling executives surround him. 'Pretty girls should always smile!' he triumphantly says.
The teaser begins with Elisabeth, gazing at herself in the mirror with her mascara smeared and a crestfallen look on her face
Elisabeth Sparkle (Moore) injects herself with the cell-replicating substance
Moore plays aging celebrity fitness instructor Sparkle
After taking The Substance she curls up into a ball in the shower
The substance transforms her into Sue (Qualley)
As Qualley's body appears on screen, the narrator continues, 'Younger. More beautiful. More perfect'
Sue turns heads as she struts in the sunshine in a white tennis skirt and pink top
The neon green liquid Sparkle injects
Near the end of the trailer, Sue is shown laying on the floor with droplets of blood splattered on her face.
Sparkles angrily smears off her lipstick in the mirror before the teaser ends.
The film, which has been met by rave reviews and received a 13-minute standing ovation at Cannes, sees Moore take part in a full-frontal nudity scene.
She previously revealed to Variety that her shock full frontal nudity scenes in acclaimed new film were easier to perform with co-star Margaret by her side.
In The Substance, Moore stars as Elisabeth, an ageing TV fitness instructor who signs up for a mysterious medical regime called The Substance that promises to create the perfect, younger and better version of herself - played by Qualley.
The role required Moore to be completely naked in a scene where Qualley's character is 'birthed' - which shows Moore examining her own nude body before Qualley emerges and looks at her own skin in a full-frontal scene.
Moore said: 'I had someone who was a great partner who I felt very safe with. We obviously were quite close — naked — and we also got a lot of levity in those moments at how absurd those certain situations were. But ultimately. it’s just about really directing your communication and mutual trust.
Sparkle gets into a terrible car accident that seems to somehow involve Sue
Sue is shown with blood on her face just before the collision occurs
Elisabeth is shown getting into a scary accident
She is flung back into her home
Moore also transforms into a deteriorating old woman through prosthetics and said: 'It was very strange. One thing that helped was my dog still recognized me. It was my touchstone of reality.'
After the film premiered it reportedly received a 13-minute standing ovation and Demi's own performance has been branded 'fearless'.
Demi's co-star Dennis referred to her Cannes comeback as a 'incredible third act' during a press conference after the film screened during the festival.
After branding her 'inspirational', Demi spoke about her own experience with making the film, which she claimed 'pushed her out of her comfort zone'.
Dennis Quaid, who plays studio head Harvey, dons a flashy orange suit as a team of smiling executives surround him. 'Pretty girls should always smile!' he triumphantly says
The Substance will be released on September 20
She said: 'I look for things that push me out of my comfort zone; the opportunity to make a better person and actor.
'This touched on so many themes that we all face, we seek validation and belonging. By doing [the movie] it takes us to extremes and allows us to step into it in a unique way.
'Through the process of the film, I think I came out with greater acceptance of myself.'
The 13-minute standing ovation after the film was the longest the 77th annual festival has seen so far, as a rapturous applause filled the theatre.
Demi said the vulnerability required for her role in the body horror film was both demanding and exciting.
The Substance will be released on September 20.
