Allantoin Is The Skin-Soothing Ingredient to Add to Your Routine

Light pink cream in a skincare container against a light pink background.

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In the beauty community, we're a little guilty of hyping up some moisturizing ingredients—think hyaluronic acid, ceramides, niacinamide, and squalane—while overlooking others that deserve the same praise. Take allantoin, for instance—the potent, healing, and soothing ingredient that's been used for centuries.

You're not alone if you don't know much about it or haven't even heard of it. Despite all of its skin benefits—including anti-aging and exfoliation properties—allantoin flies under the radar. Because we think it deserves more recognition (and a spot in your dry skincare routine), we spoke to top dermatologists Ava Shamban, MD, and Jennifer Herrmann, MD, to answer all your questions about the sensitive-skin-loving ingredient.

Ahead, discover everything you need to know about allantoin, plus how best to reap its benefits.

Meet the Expert

  • Ava Shamban, MD, is a Beverly Hills-based dermatologist who specializes in wrinkle reduction and other aesthetic skincare procedures.
  • Jennifer Herrmann, MD, FAAD, is a board-certified dermatologist specializing in lasers, Mohs surgery, cosmetic fillers, and Botox.

What Is Allantoin?

Allantoin, also known as aluminum dihydroxy allantoinate, is an extract from the comfrey plant, native to temperate climates of Asia and Europe. According to Herrmann, it has potent healing and soothing properties, and for centuries, comfrey leaves were used to help heal minor skin injuries and swelling. Additionally, it can be found in various plants, such as beets, chamomile, wheat sprouts, and even tobacco seeds.

Allantoin

Type of ingredient: Moisturizer and exfoliator.

Main benefits: Moisturizes, soothes itchiness, and heals injured skin.

Who should use it: In general, those with dry, itchy skin who are looking for even skin texture and smoothness, regardless of skin type, age, or conditions.

How often can you use it: Can be used day in and day out without general side effects of any kind, according to Shamban.

Works well with: Herrmann says when used in scar creams, allantoin is often combined with ingredients like silicone and other emollients to amplify results.

Don't use with: Herrmann adds that combining it with other exfoliants could produce an exaggerated reaction, causing excess irritation, if strengths are too high.

Shamban adds that although it can be extracted for cosmetic usages from most of these sources, more often, it's the lab-created versions we find in products. "Both versions are safe and effective when used in advanced skincare and are becoming more and more popular for efficacy and results," Shamban says.

What Products Can You Find It In?

Allantoin comes in powder form and is found in many creams and liquids, such as moisturizers, exfoliators, and masks. "Although rigorous scientific studies are lacking, there is anecdotal evidence that it helps moisturize the skin by exfoliating and removing dead skin cells that prevent natural humectants from binding and retaining water in the skin," Herrmann says.

Benefits

Allantoin is multipurpose and, as Shamban puts it, "the kind of employee you want on your team—one who can multitask and has a full range of talents." Below are eight ways allantoin can improve your skin:

  • Moisturizes: Allantoin is an emollient that moisturizes your skin and prevents dryness and irritation.
  • Soothes skin: Allantoin has the additional functionality of being a calming agent. Herrmann says it soothes and protects the skin by forming complexes with irritant and sensitizing agents.
  • Improves skin healing: Herrmann says it has been noted to help soothe injured skin and promote wound healing. It is often used to treat skin irritation and rashes.
  • Exfoliates: Herrmann adds that allantoin is also keratolytic, which means it exfoliates dead skin cells. As explained by Shamban, it helps desquamation, the shedding of the outermost membrane or layer of tissue from the inside out. 
  • Hydrates: Shamban says its keratolytic property can increase the water content of cells, fighting against the damage of transepidermal water loss (TEWL) in the dermis and keeping the skin looking plump and youthful. "Think of it as almost the expansion of a sponge when wet, holding the maximum amount of liquid," she says.
  • Improves skin dullness: Allantoin promotes cell proliferation and supports overall "remodeling," as Shamban puts it. "If the skin is stressed by the usual and customary list of offenders, then the skin is going to try to repair itself as opposed to having more cells turn over," she explains. "What we want to do with the epidermis is to have it constantly exfoliating itself and having more cells be produced because that’s how you get a faster transit time of the epidermal cells. As people get older, then that transit time from the base layer of the epidermis to the top layer takes longer, and also the skin is stressed, and those are some of the causes of dull, dry skin, too. This is going to help with that cell proliferation."
  • Smoothes skin: Herrmann says removing surface dead skin cells (stratum corneum) also helps keep the skin smooth and soft.
  • Rejuvenates the cells: Although gentle, it can still be an effective anti-aging ingredient. "Allantoin is highly beneficial in facilitating collagen synthesis," Shamban says. "As it stimulates the fibroblasts (cells responsible for producing collagen), it also boosts extracellular matrix synthesis, which is why it is a strong rejuvenator."

Potential Side Effects

In general, allantoin is non-toxic and safe for cosmetic use. "It's non-irritating, it is a gentle anti-ager in skincare and is good for most skin types, including sensitive skin or those with a range of skin conditions because it has the additional functionality of being a calming agent," Shamban says. But Herrmann adds that some people can be allergic to the ingredient, especially if used directly from crushed comfrey leaves, which should be avoided.

How to Use It

Herrmann says allantoin should be applied according to how the product containing it is directed. Shamban adds that, generally, it's safe to use the ingredient daily.

The Final Takeaway

Allantoin is an extract of the comfrey plant that soothes and provides moisture, exfoliation, and hydration when used in skincare. The ingredient is found in many creams and liquids, such as moisturizers, exfoliators, and masks, and can be used by most skin types. However, those who have itchy, dry skin may see the most benefits from allantoin. If you experience any irritation, redness, itching, or signs of an allergic reaction, seek medical advice and discontinue use until further instruction from a dermatologist.

FAQ
  • Is allantoin safe for sensitive skin?

    Allantoin is an emollient and calming agent and, therefore, safe for sensitive skin.

  • Can allantoin be used on acne-prone skin?

    As it helps remove surface dead skin cells, allantoin can help exfoliate acne-prone skin.

  • Can allantoin be used on dry skin?

    Because of its keratolytic property, allantoin can increase the water contents of cells, keeping skin hydrated, plump, and youthful.

  • Does allantoin brighten skin?

    Products containing allantoin can brighten skin tone by exfoliating the face and body of dull, dead skin cells.

Article Sources
Byrdie takes every opportunity to use high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial guidelines to learn more about how we keep our content accurate, reliable and trustworthy.
  1. Torres A, Rego L, Martins MS, et al. How to promote skin repair? In-depth look at pharmaceutical and cosmetic strategies. Pharmaceuticals. 2023;16(4):573.

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