The cynic brigade doesn't give a fuck about the outcome. They exist to whine and feel/appear correct as their cynicism creates several layers of "I told you so" to fall back on. Most of them know they'll personally be fine so this is more amusing than anything.
If by 'cynic brigade' you're referring to people calling for Biden to be replaced, I don't think this is a fair characterization. I'm a Canadian, so I don't get a vote in this, and while a Tump victory probably won't affect me much in the short term, I see the collapse of American Democracy as a catastrophically bad thing that will affect almost everyone on the planet eventually. So I'm just cheering for the Democrats, and endorsing the strategy I think gives them the best chance of winning another 4 years of survival; which is to replace Biden.
Mechanistically, replacing Biden with Harris seems simpler, but I can see the argument for other alternatives. It just seems to me that other alternatives are going to cause even more serious fractures in the Democratic party, give more ammunition to its enemies, and there just isn't enough time.
So at this point I think the best case scenario is: Joe Biden announces that he's suffering from [health issue] and that he can no longer endure the rigours of Presidenting/Campaigning; Kamala Harris becomes President and Biden gives her his full and unequivocal endorsement. The DNC puts all its weight behind building Harris up and giving her lots of opportunities to shine; she isn't great at this sort of thing, but she's better than Joe and she's just turning 60 this fall. The Republicans will through all the shit at her that they would through at any Democrat, but their narrative of "he's old and feeble and suffering from cognitive decline" just became useless... the Democrats have been dealing with the rest of the Republican arsenal since forever and they'll do about as well as they've ever done. Harris retains the Biden Team (and warchest) and can legitimately claim that her Team has a long and impressive list of accomplishments over the previous 4 years, and campaign on more to come. Ideally, she challenges Trump to another debate... she'd eat him alive. Sure she isn't as exciting to some as Elizabeth Warren, Pete Buttigieg, Stacy Abrams, or [insert your favourite up-and-coming D], but maybe she can bring one of them on board as her VP. She's certainly got better odds than Biden.
Think about it this way; anyone who's currently voting for Biden is going to be doing so for one of two general categories of reasons: they're genuinely stoked about having Biden as President, or they may not like Biden much but he's clearly better than Trump. I think the vast majority of Biden voters are in the latter category. Anyone in the latter category (actually anyone with a functioning brain) is also going to see Kamala Harris as better than Trump, so she looses none of that support. The vast majority of the people who really like Joe Biden are also going to vote for his VP rather than Trump. So Harris has at least as much support as Biden, and offers lots of things voters have never had an opportunity to vote for before (female, POC, under 60 etc.). If she has someone like Buttigieg as VP, she might even excite the under-35s that the Democrats so desperately need to turn out.
This seems like a no-brainer to me.
{edit:typos}