ONI

#dSTORM is one of the most common Single Molecule Localization Microscopy (#SMLM) methods, perfect for exploring molecular and cellular structures. To help you start your journey to new discoveries, ONI launched two kits for dSTORM #imaging: the Training Kit™: dSTORM, for first time users who are looking to polish their #microscopy expertise and the Discovery Kit™: dSTORM in cells, our ultimate kit to prepare your samples for #SuperResolution. Have a look at our guide to sample preparation & imaging with the Discovery Kit™: dSTORM in cells, so that you too can have the optimal dSTORM experiment, suited to your needs: https://lnkd.in/e4TyWF-f #Nanoimager #DiscoveryKit #TrainingKit #Biotech #Biotechnology #CellBiology #MolecularBiology #Biology #ScienceInnovation #Research

🌟 Meet George Owen, Corporate Development Associate at ONI! 🌟George embodies our core value: "We succeed when our customers meet their goals." 🤝 George believes impactful scientific discovery thrives on passionate collaboration and the right tools. Here's what George had to say about our new corporate value: "Impactful scientific discovery comes about when passionate people are able to collaborate and tackle the most challenging problems with the best tools for the job. At ONI, our customers are our collaborators, and it’s our responsibility to understand the challenges they face in their work and how we can help overcome them. We use this knowledge to build products which deliver high quality, meaningful results for the user. When our customers succeed, we succeed, and we are committed to ensuring this, every single time." 🚀#CustomerSuccess #Collaboration #ScienceImpact

The month of June was very eventful in the history of #microscopy. For today's #FluorescenceFriday we celebrate another chapter in the #HistoryOfScience, and mark 83 years for the first introduction of a fluorophore-conjugated antibody, which is now an indispensable tool in light microscopy. More than a decade before the elucidation of the double helix structure of #DNA, and years before molecular cloning became widely common, Albert Coons and his colleagues from Harvard University used chemistry to conjugate a fluorescent dye to antibodies they extracted from the serum of an inoculated rabbit. The scientists indeed tried to use the fluorescent antibodies for tissue #imaging, however, they failed, due to the overlap between the wavelength of the fluorophore and the wavelength of the tissue autofluorescence. Nonetheless, working on a compatible fluorescent antibody was already "in progress" at the time of publishing this historic paper in 1941. Today, the 28th of June, also marks the 112th birthday of Albert Coons, the scientist who pioneered the field of #immunofluorescence. Read the historic paper: https://hubs.li/Q02BBLt-0 In the image here is a #dSTORM image which used fluorescently-labeled antibodies against the mitochondrial protein Tomm20 in green and the ER protein CLIMP63 in magenta, taken using the #Nanoimager.

⭐ It's that time again! ⭐ Welcome back to ONI's weekly A-Z of Super-Resolution! Today, join us for a spotlight on "V" for Voronoi Diagram🔬 🔍 A Voronoi diagram is a mathematical method for segmenting planes into cells, where each cell is defined by the distance from a single point called a "seed." The borders of each cell represent an equal distance between one seed and another. In super-resolution microscopy, Voronoi diagrams can be used to determine the localization of labeled targets. Missed the Super-Resolution Word of the Week from the past weeks? 🤔 Catch up now! https://hubs.li/Q02DfV2D0 #CuriousMinds #SuperResolution #Microscopy #Nanoimager #VoronoiDiagram #DataSegmentation #CellLocalization

We are wishing you lots of exciting results with your new #Nanoimager!

⭐As ONI has evolved, our core values have expanded and strengthened. We are excited to announce our newest core values that guide us forward:⭐ We Find a Way 🗺️ We are proactive, collaborative problem-solvers who prioritize simplicity in our solutions. We Accelerate Discovery 🚀 We create workflows that empower impactful science and uncover hidden insights at the molecular level. We Succeed When Our Customers Meet Their Goals 👩🔬 We are dedicated to providing a high-quality experience, working closely with our customers to help them achieve outstanding results. Together We Grow 🌱 With curious minds, we embrace the roles of both teachers and students, leveraging diverse experiences to tackle complex challenges. We Set a High Bar ⛰️ We take ownership and are ambitious about the future of ONI, always striving for excellence.

With a great scientist like you, Laura Woythe, PhD, we are sure that any experiment could work, rain or shine!

Ready for another round of What's in the Image? 🔬🕵️♀️ Check out today's beautiful 2-color #dSTORM image! Can you tell what's under the lens of our talented scientists this time? #SMLM #SuperResolution #Nanoimager #imaging #microscopy #microscope #CellBiology #CellBio #biology #research #organelle

Today we celebrate 62 years to one of the scientific discoveries that changed the face of biological #research: The first paper that describes a protein with an inherent ability to emit light was published on the 25th of June 1962, in the Journal of Cellular and Comparative Physiology. The lead author of the paper, Prof Osamu Shimomura, was awarded the Nobel Prize for this discovery in 2008. This historic paper describes the chemical analyses that the researchers carried out on samples they obtained from jellyfish in an attempt to understand its light emission properties. Until that point, light emission in biological samples was known to be a result of an #enzyme with the general name of #Luciferase. Shimomura and his colleagues performed a thorough investigation and discovered that the jellyfish samples can emit light independent of an enzyme. Based on the properties of the samples, they concluded that the light emission comes from a protein, which remained active as long as the sample remained in a liquid state and in the presence of calcium. They named it Aequorin, after Aequorea, the scientific name for jellyfish species of which they used. The commonly used name, #GFP (Green Fluorescent Protein), would not be given until 1994, when the gene was cloned by Martin Chalfie and his colleagues in another historic work. Today GFP is regularly used in #ResearchLabs around the world. It is compatible with several #SuperResolution methods, including #SMLM and live cell #imaging like PALM (Photoactivated Localization Microscopy). It is hard to imagine what #LifeScience research would look like without fluorescent proteins. Read the historic paper https://hubs.li/Q02C-Qwk0 #HistoryOfScience #Fluorescence

🌟 Thank you to everyone who attended our Demo Day last Friday in San Diego! We had a full house and it was fantastic seeing so many of you. 🌟 Curious about how your samples would look at a resolution of 20nm? Don't miss the chance to request your own 1:1 demo now! https://hubs.li/Q02D26Mb0