Office of Health Economics

Inequalities in Dementia: Unveiling the Evidence and Forging a Path Towards Greater Understanding 110 inequalities affecting people living with dementia and their carers were identified across England, Wales, and Northern Ireland. With the expectation that 1 in 2 people will be impacted by dementia in their lifetime, the need for further research to inform future policy, research, and service interventions has never been more urgent.  The report was commissioned by Alzheimer's Society's to deepen our understanding of the scale and impact of inequalities in dementia and to help us identify gaps in knowledge and questions that need a long-term focused effort to address.     Key Findings  🔹Inequalities are linked to various factors including location, deprivation, socioeconomic status, age, culture, and ethnicity  🔹 Access to and experience of diagnosis and healthcare, A&E attendances, hospital admissions, and inclusion in clinical trials show significant disparities  🔹 Diagnosis rates are 5-8 percentage points lower in rural areas, with the gap widening since 2020  🔹 Gender, financial pressures, health and well-being, and systemic issues in the healthcare system contribute to inequalities.  🔹 Approximately 41% of informal carers face financial difficulties, and about 20% are out of the labour force due to caregiving responsibilities.     Proposed Recommendations and Implications  💡Improved the collection and publication of dementia data to accurately measure inequalities  💡Increased quantitative research to establish the presence and extent of these disparities    With dementia affecting nearly 1 million people in the UK, expected to rise to 1.4 million by 2040, understanding and addressing these inequalities is vital. This report highlights the need for better data and research and aligns with the core purposes of Integrated Care Systems and the NHS Long Term Plan.      Find out more from Sian Hodgson, Helen Hayes, Patricia Cubi-Molla and Martina Garau here: https://lnkd.in/dt-34gEN #dementia

OHE is excited to share the latest report and dynamic dashboard on the ROI and lives saved from incentivising new antibiotics! The model, featuring country-specific data for G7, EU, and other high-income countries, shows ROIs up to 21:1 over 30 years. You can read the report and find out about the model that has been built on Adrian Towse's work below.

🎙️Listen to the latest episode of The New Statesman Spotlight podcast featuring Gayathri Kumar and Dr adeola olaitan as they discuss with Emma Cerrone the opportunity of cervical cancer elimination in the UK and the contributing factors to reaching the World Health Organization targets for elimination of 90% vaccination and 70% cervical screening.

Join us for the OHE Annual Lecture 2024! 🌟     We are happy to announce that Professor Andrew J Scott will deliver this year's lecture, challenging conventional views on ageing and advocating a shift towards a longevity society.     In his lecture, Professor Scott will emphasise the critical importance of prevention in achieving longer, healthier lives. He will explore the transformative changes needed across society, the economy, and the health sector to transition from reactive illness care to proactive health care.     Andrew Scott, Professor of Economics at London Business School, is renowned for his work on the economics of longevity. His latest book, The Longevity Imperative – Building a Better Society for Healthier, Longer Lives, offers a compelling analysis of the socio-economic impact of increased life expectancy.     📅 Date: Tuesday, 8th October 2024  🕛 Time: 18:30  📍 Location: London The lecture will be followed by an engaging Q&A session and a drinks reception. This is a great opportunity to learn more about prevention and network with professionals dedicated to advancing health care.     Find out more and register here: https://lnkd.in/d54b-FCq #prevention #longevity

🔐 Unlocking the Value of Combination Therapies    In health economics, assessing and pricing combination therapies (CTs) remains a challenge.     Combination therapies merge treatments with different mechanisms of action, achieving greater clinical benefits than individual components alone. However, fairly attributing the value among CT components is complex, particularly when involving on-patent drugs from different manufacturers. This complexity often delays or prevents patient access. Three value attribution frameworks (VAFs) have been proposed to address such issues.      Key Findings  The current VAF:  🔸The incremental value (IV) approach faces challenges in assessing cost-effectiveness.  🔸It may not fairly attribute value, giving undue advantage to the backbone therapy. Alternative VAFs:  🔸Monotherapy Ratio (MR) approach: Addresses some issues related to the IV approach but requires full information, which is often unavailable.  🔸Generalised Approach (GA): Seen as most fair and technically correct but also needs full information. Industry Perspectives:  🔸GA received the most support for fairness and risk mitigation.  🔸IV approach ranked highest for feasibility but deemed insufficient for addressing access challenges.    Co-Creation of Solutions:  💡Collaborative efforts between industry, payers, and HTA agencies are essential.  💡 Payer and decision-maker acceptance, such as NHS England and NICE, will influence manufacturers’ choice of VAF. Recommendations:  💡 GA: Starting point for value attribution in arbitration.  💡 Supplemental Use: IV and MR approaches can complement discussions between manufacturers and payers. Read Gayathri Kumar, George Bray and Prof. Lotte Steuten, PhD's report here: https://lnkd.in/d_zbUVPj #combinationtherapy

✨ Shaping the Future: OHE's Impact at the Heart of Health Policy    Yesterday, the OHE team took centre stage at a parliamentary event in Ireland, showcasing our commitment to informing health policy at the highest levels.    On Wednesday, at an event hosted by Senator Gerry Horkan at the Parliament of Ireland, Simon Brassel presented findings from our latest report, “The Value of Adult Vaccination in Ireland”. The report, commissioned by GSK, reveals that implementing national immunisation programmes for Influenza, Pneumococcal Disease, Herpes Zoster, and Respiratory Syncytial Virus in Ireland could generate societal value worth up to €23 for every €1 spent by the Government.    The report highlighted that full implementation of these immunisation programmes in line with recommendations by the Irish National Immunisation Advisory Committee would result in ➡️73,731 fewer hospital admissions,   ➡️save 16,555 life years, and   ➡️prevent approximately 376,000 disease cases.     This underscores the immense benefits of adult vaccination, including up to €4.8 billion in net monetary benefits to society.    OHE’s Simon Brassel emphasised, “Adult immunisation programmes in Ireland offset their costs multiple times through benefits to individuals, the healthcare system, and wider society, enabling Irish people to live longer, healthier, and better lives. However, coverage and reimbursement decisions are often hampered by an underestimation of their full socioeconomic value.”    The event also featured powerful remarks from Macrina Clancy of Polio Survivors Ireland, who stressed the impact of vaccines for disease prevention, and Kate O’Connell, Pharmacist and Director of O'Connell Pharmacy Group, who highlighted the crucial role of immunisation programmes in alleviating pressure on the healthcare system.    Preventative healthcare remains at the heart of our mission as we navigate through these critical issues. The insights presented at this event highlight the multifaceted benefits of proactively addressing health challenges.    We are proud that OHE is contributing to the policy discourse in  Ireland. The engagement of our experts in these parliamentary discussions underlines our commitment to impactful research and evidence-based recommendations that contribute to the broader public health and prevention dialogue.    A special thanks to all OHE team members who contributed to this report, demonstrating our dedication to advancing health economic research.    Find out more here:   https://lnkd.in/dfAg88Tv 

✈️See you in Oxford Meet the OHE team from 8-10 July in Oxford during the HSR UK 2024 Conference. On the 9 July at 10:30 meet Grace Hampson who will present the 'Reimagining Prevention for a Healthier, More Prosperous Society' poster during the third poster walkaround session. During the fifth poster walkaround session, 9 July from 14:30, take a look at the 'Inequality in Dementia in England, Wales and Northern Ireland: Unveiling the Evidence and Forging a Path Towards Greater Understanding' poster and ask Sian Hodgson any questions. The Pecha Kucha Session 2 will take place on the 9 July at 14:30 where Margherita N. will join the 'Efficiency and productivity of general practices in England' research presentation. Register here and meet us in Oxford: https://lnkd.in/djbDDUhK

✈️The next stop is Coventry From 3 till 5 July, you can meet with the OHE team at the Scarman Conference Venue at Coventry during the HESG Summer Meeting 2024. On the first day of the conference, 3 July, Mireia Jofre-Bonet will share her insights on the 'Price effect of biosimilars on the US pharmaceutical market' panel discussion starting at 13:30 BST. Following that, at 14:30 BST Mireia Jofre-Bonet will chair the 'Social care in England: understanding need and demand' panel discussion. Chris Sampson will chair the 'Current challenges and potential solutions when evaluating the cost-effectiveness of newborn genome sequences: a long road ahead?' panel on the 4 July at 9:00 BST. On the third day of the summer meeting, 5 July at 9:00 BST, Chris Sampson will discuss 'Productivity and efficiency: measuring different things gives different results'. At the same time, 5 July at 9:00 BST, Mireia Jofre-Bonet will take part in the 'Saving lives, saving money? The effect of a suicide prevention program on a healthcare system' panel discussion. See you in Coventry, register here: https://lnkd.in/d99rHwha

✨ Time for Change ✨ Introducing the Office of Health Economics Change Initiative I am excited to announce the launch of the Change Initiative, a collaborative programme uniting organisations from across the health sector to tackle the world’s most critical problems. In an era of unprecedented crises, the need for collective action and innovative solutions has never been greater. That's why we're bringing together leaders and experts from industry, national health systems, academia, civil society, and multilateral organisations to drive positive change on a global scale. From combatting healthcare’s effect on the planet to promoting investment in preventative health measures, our mission is to create a healthier, more resilient world for everyone. I am incredibly excited to be part of this transformative Initiative, and I invite you to join us as we form a brighter, healthier future. #ChangeInitiative #GlobalHealth #UnitingForChange

The Role of Health Economics in Forging a Sustainable Future The healthcare sector's environmental footprint is vast, taken as a country it would be the fifth largest emitter globally. It is time for this to change. Enter health economics. In this new insight piece for the World Economic Forum, we explore the role the discipline is playing in tackling the environmental impact of climate change. Through out latest programme, the Change Initiative, we are working within and across sectors, from the pharmaceutical industry to civil society, identifying innovative, sustainable and most critically evidence-based solutions for the world's most pressing healthcare challenges. The Change Initiative by OHE 🟣Prioritizing prevention and population health initiatives 🟣Aligning financial and regulatory frameworks for green innovation 🟣Mapping global healthcare's environmental pressure points and exploring trade-offs Some of the pragmatic, evidence-based measures being proposed include: 💡Adopting renewable energy sources and reducing waste 💡Implementing carbon pricing and regulatory frameworks 💡Engaging pharmaceutical companies, civil society, academia, and health leaders Read Charlotte Ashton's article on the World Economics Forum site here:https://lnkd.in/dvy-xwfk