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Dealmaking pace and volumes remain lacklustre in Southeast Asia... Mars Mosqueda Jr. has the latest numbers in this report for DealStreetAsia. See…
Dealmaking pace and volumes remain lacklustre in Southeast Asia... Mars Mosqueda Jr. has the latest numbers in this report for DealStreetAsia. See…
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Today we’re thrilled to announce that PointOne has raised a $3.5M seed round, with participation from Bessemer Venture Partners, 8VC, General…
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Experience & Education
Publications
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Real-World Adherence and Persistence Associated with Nebivolol or Hydrochlorothiazide as Add-On Treatment for Hypertension.
Current Medical Research and Opinion
OBJECTIVE:
To compare adherence and persistence associated with nebivolol and hydrochlorothiazide (HCTZ) as add-on hypertension treatments.
RESEARCH DESIGN AND METHODS:
Adults with ≥1 hypertension diagnosis (ICD-9-CM 401-405) who used nebivolol or HCTZ as their first add-on antihypertensive therapy between 1/1/2008 and 9/30/2010 were identified from a large claims database. Patients had continuous enrollment for ≥1 year preceding (baseline period) and following (study period) the first…OBJECTIVE:
To compare adherence and persistence associated with nebivolol and hydrochlorothiazide (HCTZ) as add-on hypertension treatments.
RESEARCH DESIGN AND METHODS:
Adults with ≥1 hypertension diagnosis (ICD-9-CM 401-405) who used nebivolol or HCTZ as their first add-on antihypertensive therapy between 1/1/2008 and 9/30/2010 were identified from a large claims database. Patients had continuous enrollment for ≥1 year preceding (baseline period) and following (study period) the first qualifying prescription fill, and did not use nebivolol or HCTZ during the baseline period. A random sample of HCTZ patients meeting selection criteria were selected in a 3:1 ratio to nebivolol patients.
MAIN OUTCOME MEASURES:
The probability of receiving each drug, adjusted for baseline patient demographics, significantly different comorbidities, and costs was estimated using a logistic model. Inverse propensity score weights were used to balance confounding factors for between-cohort comparisons. Adherence (estimated using the medication possession ratio [MPR]) and persistence (estimated as days from initiation to the first >30 day gap in the index drug supply) at 6, 9, and 12 months were compared using weighted t tests.
RESULTS:
Baseline characteristics of nebivolol (n = 722) and HCTZ (n = 2166) patients were well balanced after weighting. At 12 months, nebivolol patients had a significantly higher MPR than HCTZ patients (0.76 vs. 0.70, P < 0.001), and medication persistence was 28 days longer (273 vs. 245 days, P < 0.001). Between-group differences were also significant at 6 and 9 months.
CONCLUSIONS:
When used as an add-on therapy for hypertension, nebivolol was associated with significantly higher rates of adherence and persistence compared with HCTZ, after adjusting for baseline differences between treatment groups. These results may be impacted by limitations inherent in insurance claims data, such as the lack of clinical information.Other authorsSee publication
Patents
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Techniques for Scam Detection and Prevention
Issued US 20190014064
Techniques for scam detection and prevention are described. In one embodiment, an apparatus may comprise an interaction processing component operative to generate a scam message example repository; submit the scam message example repository to a natural-language machine learning component; and receive a scam message model from the natural-language machine learning component in response to submitting the scam message example repository; an interaction monitoring component operative to monitor a…
Techniques for scam detection and prevention are described. In one embodiment, an apparatus may comprise an interaction processing component operative to generate a scam message example repository; submit the scam message example repository to a natural-language machine learning component; and receive a scam message model from the natural-language machine learning component in response to submitting the scam message example repository; an interaction monitoring component operative to monitor a plurality of messaging interactions with a messaging system based on the scam message model; and determine a suspected scam messaging interaction of the plurality of messaging interactions; and a scam action component operative to perform a suspected scam messaging action with the messaging system in response to determining the suspected scam messaging interaction. Other embodiments are described and claimed.
Other inventorsSee patent
Languages
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English
Native or bilingual proficiency
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Urdu
Professional working proficiency
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