BioLamina

Organ-on-Chip (OoC) devices are replacing animal models in drug development - but non-biological materials often limit their physiological relevance and performance. To replace non-degradable synthetic polymers commonly used to separate fluidic channels, Xingrui Mou and colleagues developed a Biolaminin-functionalized silk fibroin membrane, demonstrating its effectiveness in a human kidney chip in their recent study. Notably, the Biolaminin-functionalized membrane is: ➡ Biological: Enables functional remodeling of ECM and transmembrane cell communication. ➡ Ultrathin: Thinner than traditional PDMS, closely resembling the in vivo basement membrane. ➡ Consistent: Maintains molecular and conformational composition across batches.   With desirable high porosity and mechanical properties similar to the in vivo tissue, this fibroin membrane could become the new standard in OoC devices. Read the full study, Mou et al. 2024 Science Advances: 📰 https://lnkd.in/dqnQqgWe PS. Are you thinking of adding crucial biological cues to your material? Contact us! #OrganOnChip #TissueEngineering

Stem cells are picky. A recent study reveals that laminin-511 isoform is not produced at all in the human embryonic stem cell niche. 511 would never completely fill their stringent criteria. Instead, full-length laminin-521 ticks all the boxes. It is even the first basement membrane protein to appear during development, making it absolutely crucial for stem cell survival and stability. In nature, laminin proteins are always full-length and intact. Otherwise, they can’t function. Similarly, Biolaminin® proteins are always full-length. PS. Did you know that we are, in fact, the sole provider of full-length laminins? Discover the benefits of full-length laminin-521 in stem cell culture: https://lnkd.in/dMfDzmuq Got insights? Share with us! -------- See the full study about BM development during human embryogenesis, Rosner et al. 2024 Developmental Cell: https://lnkd.in/dGb-zUdj #StemCells #StemCellCulture #PSC #Laminin

Some cherry-picking done yesterday from Dr. Karl Tryggvason's, our scientific founder, cherry tree (with permission, we promise! 😉) All these delicious fruits are now ready for some molecular cooking. We will follow recipes / protocols to get the best results. Cherry-picking in science? No, thank you! With consistently performing cell culture, you don’t need to exclude replicates and cherry-pick data. See this example of how the chemically defined, biologically relevant Biolaminin substrate offers reproducibility in cardiomyocyte differentiation ➡ https://lnkd.in/dDZMmNfw #NoMoreCherryPicking #ScientificIntegrity #Biolaminin #cardiomyocyte #cellculture

Thank you for meeting us at #ISSCR2024 in Hamburg last week. We were thrilled to celebrate with you our 15th anniversary, but also take you through our poster presentations, and welcome you to our innovation showcase. We loved to learn more about your research and discuss how our full-length Biolaminin® matrices can support your cell culture. Do you have a question about our Biolaminin® matrices? Contact us now ➡ https://lnkd.in/d8YvhRha See you next year in Hong Kong, International Society for Stem Cell Research!

It is really thrilling to hear about the most significant new advances in the stem cell research and regenerative medicine fields at #ISSCR2024! On this third day, don't miss the following poster presentations: 📌 From 3:45 to 4:45, Susanne Gröndahl from BioLamina will present poster #363 “Full-length laminins are crucial for recreating the cellular niche in vitro“ 📌 From 4:45 to 5:45, Dr. Malin Kele (Eriksson) will talk about how “Recombinant laminin proteins provide a biologically relevant niche for primary cells in vitro, mimicking the natural niche for both adult stem cells and cancer cells” in her poster #408 📌From 4:45 to 5:45, Dr. Diana Chaker from INSERM, will present her poster #338 : "Generation and characterization of clinical grade human master cell banks of induced pluripotent stem cells (iPSC) with high expansion potential." Come and see how our Biolaminin® 521 Clinical Therapy Grade (CTG) and Biolaminin 521 MX were used in her scalable protocol. Bis bald! Want to learn more about our full-length laminins? Come to our booth #903 until 6:00.

Last day of exhibition at #ISSCR2024 and last chance to visit us at booth 903. We would love to hear more about you and your research. Susanne Gröndahl , Dr. Therese Kallur , Dr. Malin Kele (Eriksson), Evan L. Graham, PhD and Camille Fournier-Sandberg

Our Innovation Showcase at #ISSCR2024 starts in 30 minutes! Join us at Hall G2, Level 2, and hear from our guest speakers, Dr. Brian Hawkins and Dr. Terri Gaskell their journey toward translational success. Dr. Ilse Eidhof will also present how defined culture conditions robustly maintain human stem cell pluripotency via tightly controlled Ca2+ signaling. Refreshments will be served and you will get the opportunity to be one of our lucky winners of a gift card!

Don't miss these poster sessions in a bit! ➡ From 3:45 to 4:45, Dr. Malin Kele (Eriksson), our Director Business Development, will present poster #269: “Gene editing cells using CRISPR-Cas9 on Biolaminin® 521 improves single-cell survival and cloning, enabling consecutive differentiation of human pluripotent stem cells on biorelevant matrices” ➡ Also from 3:45 to 4:45, you might be interested in Charlotte Janssens 's poster presentation #559 "Xeno/feeder-free culture using laminin supports resetting towards naive pluripotency in human embryonic stem cells". Check how her team at the Research Group Reproduction and Genetics, Vrije Universiteit Brussel, aimed to mimic the natural environment by culturing cells on Biolaminin® LN 521, which is one of the first cell adhesion proteins present in the inner cell mass of human blastocysts. ➡ From 4:45 to 5:45, don't miss Dr. Therese Kallur, our CSO and VP Business Development! She will present poster #254 “Organ-specific expression data steer choice of laminin proteins for in vitro studies, for biologically relevant drug discovery and development platforms” See you there, bis bald!

Hallo #ISSCR2024 attendees! Are you interested in learning more about hPSC-derived #corneal limbal #stemcells? Check out Meri Vattulainen's poster #116 from Tampere University "Heterogeneity of xeno-free cultured human pluripotent stem cells (hPSC) induces variation in the differentiation efficiency of hPSC-derived corneal limbal stem cells" today from 6:45!

See you tomorrow in Hamburg for #ISSCR2024! Come by our booth #903. We would love to learn more about your research and discuss how our full-length Biolaminin® matrices can support your cell culture. Here are some activities we have for you: 🌟 Thursday, July 11 from 3:45 to 4:45: Poster #269:“Gene editing cells using CRISPR-Cas9 on Biolaminin® 521 improves single-cell survival and cloning, enabling consecutive differentiation of human pluripotent stem cells on biorelevant matrices” 🌟 Thursday, July 11 from 4:45 to 5:45: Poster #254: “Organ-specific expression data steer choice of laminin proteins for in vitro studies, for biologically relevant drug discovery and development platforms” 🌟 Thursday, July 11 from 6:00 to 6:30 Don't miss our Innovation showcase: “Biolaminin® technology: supporting standardization for translational success”- Dr. Brian Hawkins, from Pluristyx, Inc., and Dr. Terri Gaskell, from Rinri Therapeutics Ltd., will share their stories of translational success. Dr. Ilse Eidhof, from Lund University/ Karolinska Institute, will share how defined culture conditions robustly maintain human stem cell pluripotency via tightly controlled Ca2+ signaling. Pre-register now for our innovation showcase ➡ https://lnkd.in/dsgtQEX9 🌟 Friday, July 12 from 3:45 to 4:45: Poster #363: “Full-length laminins are crucial for recreating the cellular niche in vitro“ 🌟Friday, July 12 from 4:45 to 5:45: Poster #408: “Recombinant laminin proteins provide a biologically relevant niche for primary cells in vitro, mimicking the natural niche for both adult stem cells and cancer cells” Bis bald!