Dietary N-acetylcysteine supplementation alleviates liver injury in lipopolysaccharide-challenged piglets

D Yi, Y Hou, L Wang, B Ding, Z Yang, J Li…�- British Journal of�…, 2014 - cambridge.org
The present study was carried out to determine whether N-acetylcysteine (NAC) could
modulate liver injury in a lipopolysaccharide (LPS)-challenged piglet model. For this�…

[HTML][HTML] N-Acetylcysteine improves intestinal function in lipopolysaccharides-challenged piglets through multiple signaling pathways

D Yi, Y Hou, H Xiao, L Wang, Y Zhang, H Chen, T Wu…�- Amino acids, 2017 - Springer
This study determined whether N-acetylcysteine (NAC) could improve intestinal function
through phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of�…

Dietary supplementation with glutamate precursor α-ketoglutarate attenuates lipopolysaccharide-induced liver injury in young pigs

L Wang, Y Hou, D Yi, Y Li, B Ding, H Zhu, J Liu, H Xiao…�- Amino acids, 2015 - Springer
There is growing interest in glutamate as a functional amino acid in nutrition and health. This
study was conducted to determine whether glutamate precursor α-ketoglutarate (AKG) could�…

Effect of N-acetyl cysteine on enterocyte apoptosis and intracellular signalling pathways' response to oxidative stress in weaned piglets

L Zhu, X Cai, Q Guo, X Chen, S Zhu…�- British Journal of Nutrition, 2013 - cambridge.org
N-acetyl cysteine (NAC) has been widely used for preventing reactive oxygen species-
induced damage. However, little is known as to whether dietary NAC supplementation�…

N-acetylcysteine reduces inflammation in the small intestine by regulating redox, EGF and TLR4 signaling

Y Hou, L Wang, D Yi, B Ding, Z Yang, J Li, X Chen…�- Amino acids, 2013 - Springer
This study determined whether N-acetylcysteine (NAC) could affect intestinal redox status,
proinflammatory cytokines, epidermal growth factor (EGF), EGF receptor (EGFR), Toll-like�…

Protective effects of N-acetylcysteine on intestinal functions of piglets challenged with lipopolysaccharide

Y Hou, L Wang, W Zhang, Z Yang, B Ding, H Zhu, Y Liu…�- Amino acids, 2012 - Springer
The neonatal small intestine is susceptible to damage by endotoxin, but effective methods
for prevention and treatment are lacking. N-acetylcysteine (NAC) is a widely used precursor�…

Aspartate alleviates liver injury and regulates mRNA expressions of TLR4 and NOD signaling-related genes in weaned pigs after lipopolysaccharide challenge

W Leng, Y Liu, H Shi, S Li, H Zhu, D Pi, Y Hou…�- The Journal of nutritional�…, 2014 - Elsevier
Pro-inflammatory cytokines play a critical role in many models of liver injury. In addition,
aspartate (Asp) plays an important role in many biological and physiological processes�…

Asparagine attenuates hepatic injury caused by lipopolysaccharide in weaned piglets associated with modulation of Toll-like receptor 4 and nucleotide-binding�…

H Wu, Y Liu, D Pi, W Leng, H Zhu, Y Hou…�- British Journal of�…, 2015 - cambridge.org
Pro-inflammatory cytokines play a key role in many models of hepatic damage. In addition,
asparagine (Asn) plays an important role in immune function. We aimed to investigate�…

Dietary L-arginine supplementation alleviates liver injury caused by Escherichia coli LPS in weaned pigs

Q Li, Y Liu, Z Che, H Zhu, G Meng, Y Hou…�- Innate�…, 2012 - journals.sagepub.com
This study was conducted to evaluate whether dietary supplementation with l-arginine (Arg)
could attenuate Escherichia coli LPS-induced liver injury through the TLR4 signaling�…

Prophylactic effect of liposomal N-acetylcysteine against LPS-induced liver injuries

M Alipour, A Omri, MG Smith…�- Journal of Endotoxin�…, 2007 - journals.sagepub.com
The aim of this study was to evaluate and compare the effectiveness of N-acetylcysteine
(NAC) and liposomally-encapsulated NAC (L-NAC) in ameliorating the hepatotoxic effects of�…