Cancer Institute, Mechanisms of Carcinogenesis

Websitehttps://cancer.psu.edu/research/programs/mechanisms-carcinogenesis

Postal addressShow on map
United States

Organization profile

The Mechanisms of Carcinogenesis research program of Penn State Cancer Institute investigates the mechanisms of carcinogenesis induced by viruses, chemicals and environmental/dietary agents through basic research.

Novel carcinogenic mechanisms identified by the program are applied toward the prevention and treatment of human cancers in collaboration with the Cancer Control research program and the Next-Generation Therapies program.

Jordan Bisanz
- Biochemistry & Molecular Biology - Assistant Professor
- Penn State Cancer Institute
- Cancer Institute, Mechanisms of Carcinogenesis
Person: Academic
20102024
David D. Boehr, PhD
- Chemistry - Professor of Chemistry
- Penn State Cancer Institute
- Cancer Institute, Mechanisms of Carcinogenesis
Person: Academic
20002024
Margherita Teresa-Anna Cantorna, PhD
- Veterinary and Biomedical Sciences - Distinguished Professor
- Huck Institutes of the Life Sciences
- Penn State Cancer Institute
- Cancer Institute, Mechanisms of Carcinogenesis
Person: Academic
19902024
Kun-Ming Chen, PhD, MS
- Department of Biochemistry and Molecular Biology - Associate Professor
- Penn State Cancer Institute
- Cancer Institute, Mechanisms of Carcinogenesis
Person: Academic
20042024
Neil Christensen, MSc, PhD
Person: Academic
19832024
Michael Creer, MD
- Department of Pathology and Laboratory Medicine - Laurence M. Demers Professor in Pathology
- Division of Clinical Pathology - Chief
- Penn State Cancer Institute
- Cancer Institute, Mechanisms of Carcinogenesis
Person: Academic
19782024
Kristin Eckert, PhD
- Department of Pathology and Laboratory Medicine - Professor
- Division of Experimental Pathology - Chief
- Department of Biochemistry and Molecular Biology - Professor
- Penn State Cancer Institute
- Cancer Institute, Mechanisms of Carcinogenesis
Person: Academic
19872024
Karam El-Bayoumy, PhD
- Department of Biochemistry and Molecular Biology - Distinguished Professor
- Penn State Cancer Institute - Associate Director, Basic Research
- Cancer Institute, Mechanisms of Carcinogenesis
- Penn State Center for Research on Tobacco and Health
Person: Academic
19792024
Irina Elcheva, PhD
Person: Academic
19982023
Adam Bleier Glick, PhD
Person: Academic
19872024

2022-2023 Toxicological Sciences: Paper of the Year
Will, Y. & Peters, J. M., Mar 1 2024, In: Toxicological Sciences. 198, 1, p. 2-3 2 p.
Research output: Contribution to journal › Editorial › peer-review

Open Access
Accelerating the discovery of alkyl halide-derived natural products using halide depletion
Glasser, N. R., Cui, D., Risser, D. D., Okafor, C. D. & Balskus, E. P., Feb 2024, In: Nature Chemistry. 16, 2, p. 173-182 10 p.
Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations
A comprehensive review on 3D tissue models: Biofabrication technologies and preclinical applications
Xie, R., Pal, V., Yu, Y., Lu, X., Gao, M., Liang, S., Huang, M., Peng, W. & Ozbolat, I. T., Jan 2024, In: Biomaterials. 304, 122408.
Research output: Contribution to journal › Review article › peer-review

3 Scopus citations
Activation of Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ) in Keratinocytes by Endogenous Fatty Acids
Zhu, B., Zhu, X., Borland, M. G., Ralph, D. H., Chiaro, C. R., Krausz, K. W., Ntambi, J. M., Glick, A. B., Patterson, A. D., Perdew, G. H., Gonzalez, F. J. & Peters, J. M., Jun 2024, In: Biomolecules. 14, 6, 606.
Research output: Contribution to journal › Article › peer-review

Open Access
Acute kidney injury in hospitalized children with proteinuria: A multicenter retrospective analysis
Baggett, K. H., Manghi, T., Walter, V., Thomas, N. J., Freeman, M. A. & Krawiec, C., Mar 2024, In: PloS one. 19, 3 March, e0298463.
Research output: Contribution to journal › Article › peer-review

Open Access
A drug-selectable acoustic reporter gene system for human cell ultrasound imaging
Howells, A. R., Welch, P. J., Kim, J., Forest, C. R., Shi, C. & Lian, X. L., Mar 2024, In: Bioengineering and Translational Medicine. 9, 2, e10584.
Research output: Contribution to journal › Article › peer-review

Open Access
Advancing botanical safety: A strategy for selecting, sourcing, and characterizing botanicals for developing toxicological tools
Waidyanatha, S., Collins, B. J., Cristy, T., Embry, M., Gafner, S., Johnson, H., Kellogg, J., Krzykwa, J., Li, S., Mitchell, C. A., Mutlu, E., Pickett, S., You, H., Van Breemen, R. & Baker, T. R., Apr 2024, In: Food and Chemical Toxicology. 186, 114537.
Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations
Ancient and modern mechanisms compete in progesterone receptor activation
Khan, S. H., Dube, N., Sudhakar, N., Fraser, O., Villalona, P., Braet, S. M., Leedom, S., Reilly, E. R., Sivak, J., Crittenden, K. & Okafor, C. D., Apr 15 2024, In: RSC Chemical Biology. 5, 6, p. 518-529 12 p.
Research output: Contribution to journal › Article › peer-review

Open Access
An O-methylflavone from Artemisia afra kills non-replicating hypoxic Mycobacterium tuberculosis
Kellogg, J. J., Alonso, M. N., Jordan, R. T., Xiao, J., Cafiero, J. H., Bush, T., Chen, X., Towler, M., Weathers, P. & Shell, S. S., Oct 28 2024, In: Journal of Ethnopharmacology. 333, 118500.
Research output: Contribution to journal › Article › peer-review

Open Access
Association of medical comorbidities in obese subjects diagnosed with heparin-induced thrombocytopenia
Darok, M., Daly, A., Walter, V. & Krawiec, C., Jan 1 2024, In: SAGE Open Medicine. 12
Research output: Contribution to journal › Article › peer-review

Open Access

1 Not started
27 Active
199 Finished

Research Training in Physiological Adaptations to Stress
Korzick, D. H. (PI), Harvatine, K. J. (CoPI) & Cantorna, M. T.-A. (CoPI)
National Institute of General Medical Sciences
7/1/24 → 6/30/25
Project: Research project
Center: National Synthesis Center for Emergence in the Molecular and Cellular Sciences
Honavar, V. G. (CoPI) & O'Brien, Jr., E. P. (PI)
National Science Foundation
5/1/24 → 4/30/29
Project: Research project
IUCRC Phase III The Pennsylvania State University: Center for Membrane Applications, Science and Technology (MAST)
Zydney, A. (PI), Gomez, E. D. (CoPI), Arges, C. (CoPI), Sheikhi, A. (CoPI) & Oh, H. J. (CoPI)
National Science Foundation
3/1/24 → 2/28/29
Project: Research project
DREAM Sentinels: Multiplexable and programmable cell-free ADAR-mediated RNA sensing platform (cfRADAR) for quick and scalable response to emergent viral threats
Lian, X. L. (CoPI) & Guan, W. (PI)
National Science Foundation
1/1/24 → 12/31/26
Project: Research project
Developing in situ transcriptomics of a bioprinted follicular skin model
Oh, J. (PI) & Ozbolat, I. T. (CoPI)
National Institute of Arthritis and Musculoskeletal and Skin Diseases
9/20/23 → 9/14/25
Project: Research project
Metabolic Regulation of erythropoiesis
Paulson, R. (PI)
National Institute of Diabetes and Digestive and Kidney Diseases
8/15/23 → 7/31/24
Project: Research project
BIOINSPIRED ENZYMATIC MANUFACTURING OF PULSE PROTEIN HYDROGELS AS COLD/HEAT-TOLERANT FAT TEXTURIZING AGENTS
Zhang, Y. (PI)
National Institute of Food and Agriculture
8/1/23 → 7/31/27
Project: Research project
Environmental Chemical Impact on the Host-Microbiome Interaction
Patterson, A. D. (PI)
National Institute of Environmental Health Sciences
6/13/23 → 5/31/25
Project: Research project
High-throughput Spheroid Bioprinting Technology for Scalable Fabrication of Tissues
Ozbolat, I. T. (PI)
National Institute of Biomedical Imaging and Bioengineering
6/1/23 → 5/31/25
Project: Research project
IDENTIFICATION OF DIETARY PHYTOCHEMICALS TO MODULATE CHRONIC GI DISEASES
Kellogg, J. (PI)
National Institute of Food and Agriculture
4/1/23 → 3/31/27
Project: Research project

3 Oral presentation

Unraveling the controversial role of peroxisome proliferator-activated receptor-β/δ in cancer
Peters, J. M. (Keynote speaker)
2016 → …
Activity: Talk types › Oral presentation
Peroxisome proliferator-activated receptors as molecular targets for the treatment and prevention of diseases
Peters, J. M. (Invited speaker)
2009 → …
Activity: Talk types › Oral presentation
PPARβ(δ)-dependent regulation of cell proliferation, differentiation and carcinogenesis: Studies from null mouse models
Peters, J. M. (Invited speaker)
2005 → …
Activity: Talk types › Oral presentation

Dean's Award for Excellence in Teaching
Hussein, R. (Recipient), Stredny, E. (Recipient), Whitley, M. (Recipient), Mnatsakanyan, N. (Recipient), Raimundo, N. (Recipient), Zarnescu, D. (Recipient), Adams, N. (Recipient), Lanza, M. (Recipient), Kowalczyk, A. (Recipient), Travelute, C. (Recipient), Marco, C. (Recipient), Tondt, J. (Recipient), Anderson, A. (Recipient), Heron, C. (Recipient), Newman, R. (Recipient), Richard, D. (Recipient), Scartozzi, C. (Recipient), Dellasega, C. (Recipient), Akhtar, N. (Recipient), Albano-Aluquin, S. (Recipient), Chisty, A. (Recipient), Crook, T. (Recipient), Federici, E. H. (Recipient), Ingram, D. (Recipient), Lakshmanan, P. (Recipient), Mathew, A. (Recipient), Narayana, S. (Recipient), Prokop, A. (Recipient), Razjouyan, H. (Recipient), Tariq, A. (Recipient), Thompson, B. (Recipient), Thompson, E. (Recipient), Trivedi, N. (Recipient), Van Scoy, L. (Recipient), Wong, J. (Recipient), Allie, S. R. (Recipient), Browning, K. (Recipient), Evey, L. (Recipient), McLaughlin, P. (Recipient), Mamarabadi, M. (Recipient), Shankar, L. (Recipient), Bowie, E. (Recipient), Petfield, J. (Recipient), Whitaker, M. (Recipient), Aynardi, J. (Recipient), Allen, N. (Recipient), Cunningham, B. (Recipient), Gandhi, C. (Recipient), Jairath, B. (Recipient), Lutzkanin, K. M. (Recipient), Kerris, E. (Recipient), Nelson, A. (Recipient), Shook, J. (Recipient), Proctor, E. A. (Recipient), Raup-Konsavage, W. (Recipient), Romanoski, N. (Recipient), Graziane, J. (Recipient), Llorente, A. (Recipient), Nutting, S. (Recipient), Pinto, C. (Recipient), Yingst, J. (Recipient), Zhou, S. (Recipient), Mahase, S. (Recipient), Brian, P. (Recipient), Goldman, E. (Recipient), Maffie, J. (Recipient), Brahmbhatt, R. (Recipient), Fahy, A. (Recipient), Gish, J. (Recipient), Reed, M. F. (Recipient) & Tomasko, J. (Recipient), 2024
Prize
Dean’s Award for Excellence in Teaching
Hollins, L. C. (Recipient), Nisnevitch-Savarese, Z. (Recipient), Read, S. (Recipient), Rossi, J. (Recipient), Royo, M. (Recipient), Sarraf, E. (Recipient), Shah, B. (Recipient), Moldovan, G.-L. (Recipient), van Riggelen, J. (Recipient), Shantz, L. (Recipient), Yengo, C. (Recipient), Booth, J. (Recipient), Bates, E. (Recipient), Schuster, A. (Recipient), Clebak, K. (Recipient), Daniels, E. W. (Recipient), Hays, A. (Recipient), Hemerly, N. (Recipient), Thompson, A. (Recipient), George, D. (Recipient), Evey, L. (Recipient), McLaughlin, P. (Recipient), Acharya, J. (Recipient), De Jesus, S. (Recipient), O'Leary, A. (Recipient), Wright, T. (Recipient), Cantore, W. (Recipient), Pantanelli, S. (Recipient), Millard, R. (Recipient), Updegrove, G. F. (Recipient), Choi, K. (Recipient), Darowish, C. (Recipient), Dooley, A. (Recipient), Hackman, N. (Recipient), Krawiec, C. (Recipient), Oji-Mmuo, C. (Recipient), Ryan, S. (Recipient), Shedlock, A. (Recipient), Tunks, R. (Recipient), Critchfield, L. (Recipient), Bellon, A. (Recipient), Dougherty, K. (Recipient), Lagman, J. (Recipient), Mahgoub, Y. (Recipient), Dreibelbis, T. (Recipient), Richie, J. (Recipient), Wang, L. (Recipient), Methratta, S. (Recipient), Chauvin, N. (Recipient), Deutsch, M. (Recipient), Kulaylat, A. (Recipient), Paulishak, M. (Recipient), Staszak, R. (Recipient) & MacDonald, S. (Recipient), 2022
Prize
Faculty Research Grant
Stahley, S. (Recipient), 2022
Prize
Junior Faculty Research Scholar Award
Hobbs, R. (Recipient), Graziane, N. (Recipient), Kwun, H. J. (Recipient) & Stine, J. (Recipient), 2018
Prize
Outstanding Collaborative Research Team
El-Bayoumy, K. (Recipient), Manni, A. (Recipient), Richie, J. (Recipient), Liao, J. (Recipient), Vanden Heuvel, J. P. (Recipient), Demers, L. (Recipient), Dillard, J. (Recipient) & Rogers, C. J. (Recipient), 2016
Prize