Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Jul:144:155578.
doi: 10.1016/j.metabol.2023.155578. Epub 2023 May 8.

Mitochondria-SR interaction and mitochondrial fusion/fission in the regulation of skeletal muscle metabolism

Mauricio Castro-Sepulveda  1 , Rodrigo Fernández-Verdejo  2 , Hermann Zbinden-Foncea  3 , Jennifer Rieusset  4
Affiliations
Review

Mitochondria-SR interaction and mitochondrial fusion/fission in the regulation of skeletal muscle metabolism

Mauricio Castro-Sepulveda et al. Metabolism. 2023 Jul.

Abstract

Mitochondria-endoplasmic/sarcoplasmic reticulum (ER/SR) interaction and mitochondrial fusion/fission are critical processes that influence substrate oxidation. This narrative review summarizes the evidence on the effects of substrate availability on mitochondrial-SR interaction and mitochondria fusion/fission dynamics to modulate substrate oxidation in human skeletal muscle. Evidence shows that an increase in mitochondria-SR interaction and mitochondrial fusion are associated with elevated fatty acid oxidation. In contrast, a decrease in mitochondria-SR interaction and an increase in mitochondrial fission are associated with an elevated glycolytic activity. Based on the evidence reviewed, we postulate two hypotheses for the link between mitochondrial dynamics and insulin resistance in human skeletal muscle. First, glucose and fatty acid availability modifies mitochondria-SR interaction and mitochondrial fusion/fission to help the cell to adapt substrate oxidation appropriately. Individuals with an impaired response to these substrate challenges will accumulate lipid species and develop insulin resistance in skeletal muscle. Second, a chronically elevated substrate availability (e.g. overfeeding) increases mitochondrial production of reactive oxygen species and induced mitochondrial fission. This decreases fatty acid oxidation, thus leading to the accumulation of lipid species and insulin resistance in skeletal muscle. Altogether, we propose mitochondrial dynamics as a potential target for disturbances associated with low fatty acid oxidation.

Keywords: Fatty acid oxidation; Metabolic flexibility; Mitochondria dynamics; Mitochondria-associated membranes; Organelle dynamics.

PubMed Disclaimer

Conflict of interest statement

Declaration of competing interest The authors declare no competing interests.

Similar articles

See all similar articles

Cited by

Publication types

LinkOut - more resources