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. 2023 Feb 10;10(2):238.
doi: 10.3390/bioengineering10020238.

Evaluating Hydroxyapatite, Gold Nanoparticles, and Graphene-Copper as Bimodal Agents for X-ray and Computed Tomography

Bruno Pugliese Pereira  1 , Claudia Antoine  1 , Aline Oliveira da Silva de Barros  1 , Leonardo de Castro Pacífico  2 , Martha Sahylí Ortega Pijeira  1 , Alexandre Malta Rossi  3 , Eduardo Ricci-Junior  4 , Luciana Magalhães Rebelo Alencar  5 , Ralph Santos-Oliveira  1   6
Affiliations

Evaluating Hydroxyapatite, Gold Nanoparticles, and Graphene-Copper as Bimodal Agents for X-ray and Computed Tomography

Bruno Pugliese Pereira et al. Bioengineering (Basel). .

Abstract

A global need exists for new and more effective contrast agents for computed tomography and traditional X-ray modalities. Among the few options available nowadays, limitations imposed by industrial production, performance, and efficacy restrict the use and reduce the potential of both imaging techniques. The use of nanomaterials as new contrast agents for X-ray and computed tomography is an innovative and viable way to increase the options and enhance performance. In this study, we evaluated eight nanomaterials: hydroxyapatite doped with zinc (Zn-HA 10%); hydroxyapatite doped with strontium (Sr-HA 10%); hydroxyapatite without thermal treatment (HA 282 STT); thermally treated hydroxyapatite (HA 212 500 °C and HA 01.256 CTT 1000 °C); hydroxyapatite microspheres (HA microspheres); gold nanoparticles (AuNP); and graphene oxide doped with copper (Cu-GO). The results showed that for both imaging modalities; HA microspheres were the best option, followed by hydroxyapatite thermally treated at 1000 °C. The nanomaterials with the worst results were hydroxyapatite doped with zinc (Zn-HA 10%), and hydroxyapatite doped with strontium (Sr-HA 10%). Our data demonstrated the potential of using nanomaterials, especially HA microspheres, and hydroxyapatite with thermal treatment (HA 01.256 CTT 1000 °C) as contrast agents for X-ray and computed tomography.

Keywords: biomedical; diagnosis; medical; nanotechnology; radiology.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
X-ray imaging using the wrist technique (mAs 20, ms 71, and 46 Kv) of the samples Zn-HA 10% (A), Sr-HA 10% (B), HA 01.256 CTT 1000 °C (C), HA microspheres (D), AuNP (E), and Cu-GO (F).
Figure 2
Figure 2
CT imaging showing axial section (A) and coronal section (B) of the samples Zn-HA 10% (1), Sr-HA 10% (2), HA 282 STT (3), HA 212 500 °C (4), HA 01.256 CTT 1000 °C (5), HA microspheres (6), AuNP (7), and Cu-GO (8).
See this image and copyright information in PMC

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