Cytogenetic location: 10q22-q23 Genomic coordinates (GRCh38): 10:68,800,001-95,300,000
| Location | Phenotype |
Phenotype MIM number |
Inheritance |
Phenotype mapping key |
|---|---|---|---|---|
| 10q22-q23 | {Migraine, with or without aura, susceptibility to, 12} | 611706 | Autosomal dominant | 2 |
For a general phenotypic description and a discussion of genetic heterogeneity of migraine headaches, see MGR1 (157300).
Anttila et al. (2008) provided evidence for a migraine susceptibility locus on chromosome 10q22-q23. The authors used alternative migraine phenotyping methods, including latent-class analysis and trait-component analysis, which are more inclusive than the strict criteria of the International Headache Society (IHS), to perform genomewide linkage analysis. The study included 3 cohorts: 690 Finnish patients, 661 Australian patients, and a replication cohort of 324 Finnish patients (a total of 1,675 individuals from 210 families). The initial Finnish study yielded highly significant lod scores ranging from 3.90 to 5.18 at 10q22-q23. Female-specific analysis strengthened the results to a lod score of 7.68. The Australian sample showed a lod score of 3.50, and the independent Finnish replication study yielded a lod score 2.41 at the same locus. A shared-segment analysis of 10q22-q23 linked Finnish families identified a 1.6- to 9.5-cM segment, centered on 101 cM, which showed in-family homology in 95% of affected Finns. Linkage was found with symptoms including formal IHS diagnosis, unilaterality, pulsation, and phonophobia, among others. The consistency of the linkage across studies with different ascertainment schemes and phenotyping methods provided strength for the findings. Anttila et al. (2008) concluded that the findings supported the use of symptomatology-based phenotyping in migraine, and suggested that the 10q22-q23 locus probably contains 1 or more migraine susceptibility variants.
Anttila, V., Nyholt, D. R., Kallela, M., Artto, V., Vepsalainen, S., Jakkula, E., Wennerstrom, A., Tikka-Kleemola, P., Kaunisto, M. A., Hamalainen, E., Widen, E., Terwilliger, J., and 9 others. Consistently replicating locus linked to migraine on 10q22-q23. Am. J. Hum. Genet. 82: 1051-1063, 2008. [PubMed: 18423523] [Full Text: https://doi.org/10.1016/j.ajhg.2008.03.003]