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Age-associated defects in dendritic cells can be corrected by hyperactivating adjuvants containing an oxidized phospholipid to induce effective antitumour responses in mice.
In this Comment article, organizers of the International School of Immunotherapy (Immunoschool) reflect on the experience gained from the past ten years in using online technologies for global and inclusive immunology education.
A preprint by Stevens et al. establishes a novel mechanism by which the gut micobiota provides protection against neonatal respiratory tract infection.
An adoptive cellular therapy based on γδ T cells, which were engineered to secrete a tumour-targeting opsonin as well as an IL-15 superagonist, controlled tumour growth in a mouse model of patient-derived osteosarcoma.
A study by Nakayama et al. shows that heart failure causes epigenetic changes in haematopoietic stem cells that predispose to further heart disease and comorbidity.
This Comment discusses the potential effects of ultra-processed foods (UPFs) on the immune system independently of obesity, by which UPFs might dysregulate the balance between the gut microbiota and immune cells.
A preprint by Ben-Chetrit et al. investigates the molecular and cellular mechanisms that regulate macrophage heterogeneity in solid breast cancer tumours.
Two papers in Immunity report the effects of acetylcholine secretion by intestinal tuft cells on epithelial cells and helminths that contribute to the anti-helminth response.
In this Tools of the Trade article, Sandra Nakandakari-Higa (of the Gabriel Victora lab) describes the latest version of their LIPSTIC technique for tracking diverse cell–cell interactions in vivo.