Volume 2 Issue 7, July 2024

Viruses can be engineered to deliver nucleic acids, peptides and proteins for plant trait reprogramming. Building on market approvals and sales of recombinant virus-based biopharmaceuticals for veterinary and human medicine, similar innovations may be applied to agriculture for transient or heritable biodesign of crops with improved performance and sustainable production.

Smart food packaging technologies can actualize real-time, in situ food quality monitoring, increasing food safety and decreasing food waste. Here, we detail challenges that hinder the commercialization of such smart packaging systems and identify opportunities to facilitate their translation from prototype to product.

Fats and oils are crucial dietary supplements for human health. However, animal fats and palm oil dominate the food industry, with concerns over health and the environment that call for the development of fat alternatives. The fat industry offers a vast market potential, with several startups pioneering new technical solutions and attracting venture capital interest.

An article in Nature Communications reports a metabolic modelling-based framework to construct synthetic microbiomes that can degrade specific herbicides in soil.

Motion artefacts challenge the translational application of soft bioelectronics by distorting physiological monitoring. This Review introduces fundamental causes of motion artefacts and discusses various management strategies, including materials usage, bioelectronics design and algorithmic intervention.

The organic electrochemical transistor stands out as a tool for constructing powerful biosensors owing to its high signal transduction ability and adaptability to various geometrical forms. However, the performance of organic electrochemical transistors relies on stable and seamless interfaces with biological systems. This Review examines strategies to improve and optimize interfaces between organic electrochemical transistors and various biological components.

Hydrogels are being explored and clinically applied for a variety of biomedical and clinical applications. This Review outlines a model-based modular hydrogel design framework that is application-driven and considers clinical translation early in the design process, emphasizing the importance of fundamental modelling and standardized design.

Organoids and organs-on-chips aim to improve drug testing and disease modelling, but each has limitations. This Review discusses the integration of these systems to improve cellular hierarchy, structural fidelity, reproducibility, throughput, scale-up and efficiency to improve translational outcomes.

Using nanoparticles featuring anisotropic characteristics is a promising approach to developing multifunctional platforms for drug delivery and theranostics. This Review discusses methods to generate anisotropy in nanosystems and strategies to control particle transport, targeting and interaction with cells to overcome biological barriers.