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Cardiac fibrosis

Targeting metabolically activated fibroblasts in the failing heart

Nature Cardiovascular Research (2024)Cite this article

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Myofibroblast activation requires nuclear translocation of ATP citrate lyase (ACLY) that triggers chromatin remodeling and the induction of fibrosis-associated genes. ACLY inhibition prevents myofibroblast conversion and causes de-differentiation of myofibroblasts to fibroblasts, indicating a potential therapeutic approach for heart failure.

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Fig. 1: ACLY stimulates cardiac fibrosis in heart failure.

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Acknowledgements

N.G.F.’s laboratory is supported by National Institutes of Health (NIH) grants R01 HL76246, R01 HL85440 and R01 HL149407, and by US Department of Defense grant PR211352.

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Authors and Affiliations

  1. The Wilf Family Cardiovascular Research Institute, Department of Medicine (Cardiology), Albert Einstein College of Medicine, New York City, NY, USA

    Nikolaos G. Frangogiannis

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  1. Nikolaos G. Frangogiannis
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Correspondence to Nikolaos G. Frangogiannis.

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The author declares no competing interests.

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Frangogiannis, N.G. Targeting metabolically activated fibroblasts in the failing heart. Nat Cardiovasc Res (2024). https://doi.org/10.1038/s44161-024-00500-5

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