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Immunological consequences of compromised ocular immune privilege accelerate retinal degeneration in retinitis pigmentosa
BackgroundRetinitis pigmentosa (RP) is a hereditary retinal disease which leads to visual impairment. The onset and progression of RP has...
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Somatic-Immune Cells Crosstalk In-The-Making of Testicular Immune Privilege
Immunological infertility contributes significantly to the etiology of idiopathic male infertility. Shielding the spermatogenic cells from systemic...
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How does age determine the development of human immune-mediated arthritis?
Does age substantially affect the emergence of human immune-mediated arthritis? Children do not usually develop immune-mediated articular...
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Immune Checkpoint Molecules and Maternal–Fetal Immunity
Purpose of ReviewBecause the fetus expresses paternally-derived foreign antigens, pregnancy poses unique immune challenges. The maternal immune...
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Innate immune memory in inflammatory arthritis
The concept of immunological memory was demonstrated in antiquity when protection against re-exposure to pathogens was observed during the plague of...
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Update on Immune Checkpoint Inhibitor-Associated Uveitis
Purpose of ReviewIn this article, we review the current updates on immune checkpoint inhibitors (ICPIs) and the management of ICPI-associated uveitis.
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The role of lymphatic vessels in corneal fluid homeostasis and wound healing
The cornea, essential for vision, is normally avascular, transparent, and immune-privileged. However, injuries or infections can break this...
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Immune cells: potential carriers or agents for drug delivery to the central nervous system
Drug delivery systems (DDS) have recently emerged as a promising approach for the unique advantages of drug protection and targeted delivery....
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In vivo confocal microscopy evaluation of infiltrated immune cells in corneal stroma treated with cell therapy in advanced keratoconus
PurposeThis study investigates immune cell (ICs) infiltration in advanced keratoconus patients undergoing autologous adipose-derived adult stem cell...
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Innate immune responsive inflammation in development of progressive myopia
PurposeInflammation has been implicated for development of myopia. It is not clear when inflammation is kicked in during the course of myopia, and...
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Infection and inflammation: radiological insights into patterns of pediatric immune-mediated CNS injury
The central nervous system (CNS) undergoes constant immune surveillance enabled via regionally specialized mechanisms. These include selectively...
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Immune-mediated diseases and subsequent risk of alopecia areata in a prospective study of US women
IntroductionAlopecia areata (AA) is the most common form of immune-mediated hair loss. Studies have begun to establish the most frequent comorbid...
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The role of immune checkpoint inhibitors in patients with intracranial metastatic disease
Intracranial metastatic disease (IMD) complicates the course of nearly 2–4% of patients with systemic cancer. The prevalence of IMD has been...
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Investigation of the immune escape mechanism of Treponema pallidum
BackgroundSyphilis is a chronic sexually transmitted disease caused by Treponema pallidum subspecies pallidum ( T. pallidum ), which is a public...
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Immune Evasion of Hepatoma Cancer Stem-Like Cells from Natural Killer Cells
BackgroundPoor prognosis in liver cancer is due to its high frequency of intrahepatic metastasis. Cancer stem-like cells (CSLCs), which possess the...
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9-cis-retinoic acid signaling in Sertoli cells regulates their immunomodulatory function to control lymphocyte physiology and Treg differentiation
BackgroundTestis is an immune privileged organ, which prevents the immune response against sperm antigens and inflammation. Testicular cells...
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The Future of Checkpoint Inhibitors in Uveal Melanoma: A Narrative Review
IntroductionImmune checkpoint inhibitors have made tremendous progress over the last decade in the treatment of cutaneous melanoma, but their...
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Gestational immune activation disrupts hypothalamic neurocircuits of maternal care behavior
Immune activation is one of the most common complications during pregnancy, predominantly evoked by viral infections. Nevertheless, how immune...
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Heterogeneity of the tumor immune microenvironment and its clinical relevance
During the course of tumorigenesis and subsequent metastasis, malignant cells gradually diversify and become more heterogeneous. Consequently, the...
