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Clinical significance of human endogenous retrovirus K (HERV-K) in multiple myeloma progression
Human endogenous retroviruses (HERVs) are retrotransposons that infect human germline cells and occupy 5–8% of the human genome. Their expression,...
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Patients with psychosis spectrum disorders hospitalized during the COVID-19 pandemic unravel overlooked SARS-CoV-2 past infection clustering with HERV-W ENV expression and chronic inflammation
Epidemiology has repeatedly associated certain infections with a risk of further developing psychiatric diseases. Such infections can activate...
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Identification of inflammatory subgroups of schizophrenia and bipolar disorder patients with HERV-W ENV antigenemia by unsupervised cluster analysis
Human endogenous retroviruses (HERVs) are remnants of infections that took place several million years ago and represent around 8% of the human...
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Insertional Variations of Human Endogenous Virus K6 and K11 in Normozoospermic Men
Male infertility is a multifactorial heterogeneous reproductive disorder in which genetic, epigenetic, and environmental factors play a role in the...
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Molecular mechanisms of syncytin-1 in tumors and placental development related diseases
Human endogenous retroviruses (HERVs) have evolved from exogenous retroviruses and account for approximately 8% of the human genome. A growing number...
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Pathological manifestation of human endogenous retrovirus K in frontotemporal dementia
BackgroundBehavioral variant frontotemporal dementia (bvFTD) is a common form of younger-onset dementia with a proportion of cases overlapping...
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Human endogenous retrovirus, HERV-P and HERV-R in pediatric leukemia patients
The “HERVs” (human endogenous retroviruses) are a family of endogenous retroviruses integrated into the germ cell DNA of primate over than 30 million...
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Overexpression of endogenous retroviruses in children with celiac disease
Human endogenous retroviruses (HERVs) represent 8% of our genome. Although no longer infectious, they can regulate transcription of adjacent cellular...
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A comprehensive investigation of human endogenous retroviral syncytin proteins and their receptors in men with normozoospermia and impaired semen quality
PurposeThe study aims to investigate first the presence of Syncytin 2 and its receptor, MFSD2, in human sperm, and second whether the expressions of...
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Dynamic LTR retrotransposon transcriptome landscape in septic shock patients
BackgroundSepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. Numerous studies have...
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The presence and clinical significance of autoantibodies in amyotrophic lateral sclerosis: a narrative review
Amyotrophic lateral sclerosis (ALS) is a debilitating and rapidly fatal neurodegenerative disease, which is characterized by the selective loss of...
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Temelimab, an IgG4 Anti-Human Endogenous Retrovirus Monoclonal Antibody: An Early Development Safety Review
IntroductionTemelimab (formerly called GNbAC1) is an immunoglobulin (Ig) G4 monoclonal antibody that targets the human endogenous retroviral envelope...
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Human Endogenous Retroviruses and Type 1 Diabetes
Purpose of the ReviewThe aim of this review is to discuss recent data pointing at an involvement of human endogenous retroviruses (HERVs) in type 1...
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Assessment of viral RNA in idiopathic pulmonary fibrosis using RNA-seq
BackgroundNumerous publications suggest an association between herpes virus infection and idiopathic pulmonary fibrosis (IPF). These reports have...
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Interrelation of MicroRNAs and Transposons in Aging and Carcinogenesis
AbstractThe dysregulation of transposable elements plays a key role in human carcinogenesis. Physiological aging in humans is also caused by the...
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The relationship between SARS-CoV-2 infection and type 1 diabetes mellitus
Environmental factors, in particular viral infections, are thought to have an important role in the pathogenesis of type 1 diabetes mellitus (T1DM)....
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Longitudinal analysis and treatment of neuropsychiatric symptoms in post-acute sequelae of COVID-19
BackgroundPersistent neuropsychiatric symptoms following acute COVID-19 infection are frequently reported. These include anxiety, depression,...
