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Translating neuroimaging changes to neuro-endophenotypes of autistic spectrum disorder: a narrative review
BackgroundAutism-spectrum disorder is a neurodevelopmental disorder with heterogeneity in etiopathogenesis and clinical presentation. Neuroanatomical...
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Identification of plasma metabolites associated with modifiable risk factors and endophenotypes reflecting Alzheimer’s disease pathology
Modifiable factors can influence the risk for Alzheimer’s disease (AD) and serve as targets for intervention; however, the biological mechanisms...
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Neurexin1α knockout rats display oscillatory abnormalities and sensory processing deficits back-translating key endophenotypes of psychiatric disorders
Neurexins are presynaptic transmembrane proteins crucial for synapse development and organization. Deletion and missense mutations in all three...
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Evaluating endophenotypes for bipolar disorder
BackgroundPhenotypic heterogeneity is a major impediment to the elucidation of the neurobiology and genetics of bipolar disorder. Endophenotype could...
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Quantitative trait locus analysis for endophenotypes reveals genetic substrates of core symptom domains and neurocognitive function in autism spectrum disorder
Autism spectrum disorder (ASD) represents a heterogeneous group of neurodevelopmental disorders and is largely attributable to genetic risk factors....
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BDNF haploinsufficiency induces behavioral endophenotypes of schizophrenia in male mice that are rescued by enriched environment
Brain-derived neurotrophic factor (BDNF) is implicated in a number of processes that are crucial for healthy functioning of the brain. Schizophrenia...
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Threshold for copulation-induced analgesia varies according to the ejaculatory endophenotypes in rats
Analgesia may be modulated by multiple internal and external factors. In prior studies, copulatory-induced analgesia was demonstrated using the...
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Patient outcomes in idiopathic scoliosis are associated with biological endophenotypes: 2020 SOSORT award winner
PurposeBracing is the treatment of choice for idiopathic scoliosis (IS), unfortunately factors underlying brace response remain unknown. Clinicians...
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Association of neurotransmitter pathway polygenic risk with specific symptom profiles in psychosis
A primary goal of psychiatry is to better understand the pathways that link genetic risk to psychiatric symptoms. Here, we tested association of...
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Impulsivity and Impulsivity-Related Endophenotypes in Suicidal Patients with Substance Use Disorders: an Exploratory Study
Suicidal behavior (SB) is a major problem in patients with substance use disorders (SUDs). However, little is known about specific SB risk factors in...
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Working memory and reaction time variability mediate the relationship between polygenic risk and ADHD traits in a general population sample
Endophenotypes are heritable and quantifiable traits indexing genetic liability for a disorder. Here, we examined three potential endophenotypes,...
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Advanced glycation end products measured by skin autofluorescence and subclinical cardiovascular disease: the Rotterdam Study
BackgroundAdvanced glycation end products (AGEs) have been linked to cardiovascular disease (CVD), especially coronary heart disease (CHD), but their...
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Effects of diabetes mellitus and glycemic traits on cardiovascular morpho-functional phenotypes
BackgroundThe effects of diabetes on the cardiac and aortic structure and function remain unclear. Detecting and intervening these variations early...
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Trans-ancestry meta-analysis of genome wide association studies of inhibitory control
Deficits in effective executive function, including inhibitory control are associated with risk for a number of psychiatric disorders and...
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Early-life trauma endophenotypes and brain circuit–gene expression relationships in functional neurological (conversion) disorder
Functional neurological (conversion) disorder (FND) is a neuropsychiatric condition whereby individuals present with sensorimotor symptoms...
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Circulating metabolite profile in young adulthood identifies long-term diabetes susceptibility: the Coronary Artery Risk Development in Young Adults (CARDIA) study
Aims/hypothesisThe aim of this work was to define metabolic correlates and pathways of diabetes pathogenesis in young adults during a subclinical...
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Genetic substrates of bipolar disorder risk in Latino families
Genetic studies of bipolar disorder (BP) have been conducted in the Latin American population, to date, in several countries, including Mexico, the...
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Endophenotypical drift in Huntington’s disease: a 5-year follow-up study
BackgroundHuntington’s disease (HD) is clinically characterized by progressing motor, cognitive and psychiatric symptoms presenting as varying...
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A paradigm shift in translational psychiatry through rodent neuroethology
Mental disorders are a significant cause of disability worldwide. They profoundly affect individuals’ well-being and impose a substantial financial...
